69663-47-4Relevant academic research and scientific papers
1-[(10,11-DIHYDRO-5H-DIBENZO[A,D]-CYCLOHEPTEN-5-YL)METHYL]-4-SUBSTITUTED PIPERIDINES AND RELATED COMPOUNDS
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, (2008/06/13)
The invention encompasses 1-10,11-dihydro-5H-dibenzo a, d!cyclohepten-5-yl)methyl!-4-substituted piperidines and related compounds of the formula STR1 and the non-toxic pharmaceutically acceptable acid addition salts thereof; wherein R in each occurrence represents hydrogen, halogen, alkyl radical of 1 to 7 carbon atoms, or trifluoromethyl, alike or different; R. sup.1 is hydrogen or alkyl radical of 1 to 7 carbon atoms; Z is hydroxy or NR. sup.2 R 3 group wherein R. sup.2 and R 3 are each hydrogen or alkyl radical of 1 to 7 carbon atoms or R 2 and R. sup.3 together with the N-atom represent an azamonocyclic ring which contains from 4 to 6 carbon atoms; X is ethylene, vinylene, oxy or thio; and m and n are each alike or different integer from 1 to 4 inclusive; and 1-(2,2-diarylethyl)-4-piperidinols of the formula STR2 and the non-toxic pharmaceutically acceptable acid addition salts thereof; wherein Ar is phenyl optionally substituted with one or more halogen or alkyl radical of 1 to 7 carbon atoms, alike or different; Ar. sup.1 is phenyl optionally substituted with one or more halogen or alkyl radical of 1 to 7 carbon atoms alike or different; and R. sup.4 is selected from the group consisting of hydrogen alkyl radical of 1 to 7 carbon atoms, 4-hydroxy-1-(2,2-diphenylethyl)-3-piperidinyl, and 4-oxo-1-(2,2-diphenylethyl)-3-piperidinyl. These compounds possess utility as neuroleptic agents.
Use of the butaclamol template in a search for antipsychotic agents with lessened side effects
Kukla,Bloss,Brougham
, p. 401 - 406 (2007/10/09)
A number of molecular similarities between the antipsychotic agents butaclamol and clozapine were noted. Based on the premise that this was a strong indicator of a common mechanism of action (i.e., binding at the antagonist state of dopamine receptor), a
