69677-92-5

Upstream product

• 88105-64-0 N-benzoyl-L-prolyl-L-phenylalanyl-N^ω-nitro-L-arginine 
• 5874-58-8 N-(benzoyl)-L-proline 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 88105-63-9 N-benzoyl-L-prolyl-L-phenylalanyl-N^ω-nitro-L-arginine methyl ester 
• 88105-62-8 N-benzoyl-L-prolyl-L-phenylalanine benzyl ester 
• 59191-06-9 N-benzoyl-L-prolyl-L-phenylalanine 
• 92010-20-3 (S)-1-benzoyl-pyrrolidine-2-carboxylic acid benzyl ester 
• 98-88-4 benzoyl chloride 
• 2462-32-0 L-phenylalanine benzyl ester hydrochloride 

Relevant academic research and scientific papers

Tri- and tetrapeptide analogues of kinins as potential renal vasodilators

Tri- and tetrapeptide analogues were synthesized and evaluated as renal vasodilators. These peptides were prepared by standard coupling reactions which also provided good yields with hindered α-methyl amino acid derivatives. Preliminary evidence of renal vasodilator activity was determined in anesthetized dogs by measuring the effects on renal blood flow and calculating the accompanying changes in renal vascular resistance. The most potent compounds contained, in their structure, the L-prolyl-DL-α-methylphenylalanyl-L-arginine and L-prolyl-DL-α-methyl-phenyalanylglycyl-L-proline arrays. Substitution on the N-terminal proline with 4-phenylbutyryl and 4-(4-hydroxyphenyl)butyryl side chains produced enhanced renal vasodilator activity and, in certain cases, selectivity for the renal vasculature.