69697-46-7Relevant articles and documents
Synthesis method of 4-substituent cyclohexanone
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Paragraph 0038; 0040-0041; 0046-0049, (2021/05/12)
The invention discloses a synthesis method of 4-substituent cyclohexanone, which comprises the following steps: by taking a 4-substituent phenol compound as a raw material, carrying out catalytic hydrogenation on 4-substituent phenol to obtain 4-substituent cyclohexanol, and then oxidizing the 4-substituent cyclohexanol by taking oxygen-containing gas as an oxidant to prepare the 4-substituent cyclohexanone. The oxygen-containing gas is used as the oxidizing agent, the oxygen-containing gas is low in price, good in reaction selectivity, high in oxidation reaction yield and environment-friendly, and is an ideal clean oxidizing agent; in addition, the whole synthesis process is simple, mild in condition, simple in post-treatment, green, environment-friendly and suitable for large-scale industrial production.
Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins
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, (2011/11/30)
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.
NOVEL COMPOUNDS-300
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Page/Page column 17, (2009/12/02)
Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4, m, n, q, s, t, X, and Y are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.