697-25-6

Usage

Uses

Used in Pharmaceutical Industry:
Tricyclo[2.2.1.0~2,6~]heptane-1-carboxylic acid is used as a starting material for the synthesis of various drugs and bioactive molecules due to its unique molecular structure and properties.
Used in Chemical Research:
Tricyclo[2.2.1.0~2,6~]heptane-1-carboxylic acid is used as a subject for studies in molecular modeling and stereochemistry, taking advantage of its conformational flexibility and stereochemical properties.
Used in Organic Synthesis:
Tricyclo[2.2.1.0~2,6~]heptane-1-carboxylic acid is used as a key intermediate in the synthesis of complex organic compounds, leveraging its stability and structural attributes for the development of novel chemical entities.

Upstream product

• 542-92-7 cyclopenta-1,3-diene 
• 814-68-6 acryloyl chloride 

Relevant academic research and scientific papers

Monoamine oxidase-catalyzed oxidation of endo,endo-2-amino-6-[(Z)-2'-phenyl]ethenylbicyclo[2.2.1]heptane, a potential probe for a radical cation intermediate

An 11-step synthesis of endo,endo-2-amino-6-[(E)-2'-phenyl]ethenylbicyclo[2.2.1]heptane (6) and the corresponding (Z)-isomer (7) was carried out in an attempt to make a compound that could trap the purported amine radical cation intermediate during monoamine oxidase (MAO)-catalyzed oxidation of amines. The E-isomer was not a substrate for MAO, and the Z-isomer was a very poor substrate. No trapping product was observed. Possible explanations for the inability of these compounds to trap a potential radical cation intermediate are discussed. Copyright (C) 2000 Elsevier Science Ltd.

Die Hydrolyse von 6exo-substituierten 2exo- und 2endo-Norbornylestern der p-Toluolsulfonsaeure

Hydrolysis of the 6exo-substituted 2exo- and 2endo-norbornyl p-toluenesulfonates 1b-l and 2b-l, respectively, in 70percent dioxane led to different amounts of the following products: Unrearranged 2exo-norbornanols 3 and norbornenes 5, accompained in somes cases by small amounts of the rearranged Rendo-epimers 4 and 6 and by nortricyclenes 7.When the 6exo-substituent was a nucleophile group as in 1e-l and 2e-l, various amounts of tricyclic products were also formed by endo-cyclozation.These results show that the 2exo- and 2endo-esters 1 and 2, respectively, react by way of different intermediates.In cases where the 6exo-substituent was an n-electron donor, as in 1m-r and 2m-r, quantitative fragmentation to (3-cyclopentenyl)acetaldehyde (13) occurred.