6970-25-8Relevant academic research and scientific papers
Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data
Aryal, Uma K.,Bailey, Barbara J.,Bum-Erdene, Khuchtumur,Corson, Timothy W.,Fishel, Melissa L.,Lee, Jonathan A.,Liu, Sheng,Meroueh, Samy O.,Pollok, Karen E.,Sishtla, Kamakshi,Wan, Jun,Wells, Clark D.,Xu, David,Zhou, Donghui
, p. 1424 - 1444 (2020/07/15)
Like most solid tumors, glioblastoma multiforme (GBM) harbors multiple overexpressed and mutated genes that affect several signaling pathways. Suppressing tumor growth of solid tumors like GBM without toxicity may be achieved by small molecules that selec
Synthesis and Antineoplastic Activity of 5-N-Alkyl-2-p-substituted-benzenesulphonyl-L-glutamines
De, A. U.,Pandey, Jiten,Majumdar, Anjali
, p. 481 - 483 (2007/10/02)
5-N-Alkyl-2-p-substituted-benzenesulphonyl-l-glutamines (III) have been synthesised and their antineoplastic potency evaluated in Ehrlich ascites carcinoma (EAC) in Swiss albino mice.A few of the compounds show appreciable activity.An interesting phenomenon of C-N bond cleavage has been observed when 2-p-toluenesulphonyl-L-glutamine (III; X = CH3, R = H) is treated with PPA.
