697217-20-2

Upstream product

• 55739-20-3 benzyl (2R)-2-(3-tert-butoxycarbonylaminopropionyloxy)-4-methylpentanoate 
• 20312-37-2 (R)-2-hydroxy-4-methylpentanoic acid 
• 100-39-0 benzyl bromide 
• 37755-48-9 benzyl (R)-2-hydroxy-4-methylpentanoate 

Downstream Products

• 728032-80-2 benzyl (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoate 
• 728032-81-3 benzyl (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoate 
• 728032-82-4 (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoic acid 
• 728032-83-5 (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoic acid 
• 728032-85-7 tert-butyl (5S,6R)-5-[(2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),7(E)-dienoate 
• 728032-84-6 tert-butyl (5S,6R)-5-[(2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),7(E)-dienoate 
• 728032-78-8 6-demethyldesepoxy-3-epicryptophycin-1 
• 162600-54-6 (5α)-3-epicryptophycin-24 
• 162600-54-6 3-epicryptophycin-24 
• 728032-77-7 desepoxy-3-epicryptophycin-24 

Relevant academic research and scientific papers

Total synthesis and anti-tubulin activity of epi-C3 analogues of cryptophycin-24

Epi-C3-cryptophycin-24, epi-C3-m-chlorobenzyl-cryptophycin-24, and the corresponding styrenes were synthesized and tested in vitro against the MCF-7 and multidrug-resistant MCF-7/ADR breast cancer cell lines and in an in vitro tubulin assembly assay. The results demonstrate that the S configuration at the C3 stereocenter is not required to induce potent cytotoxicity and the m-Cl substituent present on the C10 side chain did not induce any large change in activity.