697235-28-2Relevant academic research and scientific papers
Design and synthesis of novel cytotoxic podophyllotoxin derivatives
Xi, Wen Li,Cai, Qian,Tang, Yan Bo,Sun, Hua,Xiao, Zhi Yan
, p. 1153 - 1156 (2010)
In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives, novel 4-N- and 4-C-substituted 4'-O-demethylepipodophyllotoxin derivatives were designed and synthesized. All the compounds were tested against A549 and MCF-7 tumor cells in vitro, and six compounds showed significant cytotoxicity. The most active compound 9f was superior to GL-331, and exhibited potent cytotoxicity with IC50 value at 10-7mol/L level.
