697235-38-4Relevant articles and documents
SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
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Page/Page column 102, (2018/01/15)
The invention relates generally to a silvestrol molecule activated with a leaving group. The invention further relates generally to an antibody-drug conjugate comprising an antibody conjugated by a linker to one or more silvestrol drug moieties and methods of treatment.
Enantioselective synthesis of the complex rocaglate (-)-silvestrol
Gerard, Baudouin,Cencic, Regina,Pelletier, Jerry,Porco Jr., John A.
, p. 7831 - 7834 (2008/09/19)
The total synthesis of the natural product (-)-silvestrol (1) has been accomplished and features enantioselective [3+2] photocycloaddition of a substituted 3-hydroxyflavone and methyl cinnamate promoted by a chiral Bronsted acid. Initial biological studies indicate a 5-10-fold greater activity of silvestrol as an inhibitor of protein synthesis in HeLa cells than its 1″″ diastereomer.
PROCESSES AND INTERMEDIATES
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Page/Page column 84, (2010/02/15)
The present invention relates to synthetic processes for the preparation of compounds bearing a dioxanyl moiety, in particular to compounds bearing a dioxanyl side chain attached to a mono- or polycyclic core moiety, more particularly a cyclopentabenzofuran core moiety. The invention also relates to intermediate compounds used in these processes. Compounds which can be prepared by the process of the invention can be used as candidates for screening for potential therapeutic activity, thus the invention also relates to compounds obtainable or prepared by the methods described above, in particular to those having cytotoxic or cytostatic activity.