697236-30-9Relevant academic research and scientific papers
Facile zeolite induced Fischer-indole synthesis: A new approach to bioactive natural product rutaecarpine
Mhaske, Santosh B.,Argade, Narshinha P.
, p. 3417 - 3420 (2004)
Starting from glutaric anhydride (5) we have demonstrated an elegant six-step practical synthesis of bioactive natural product rutaecarpine (1a) via o-amidoglutaranilic acid formation, esterification, chemoselective ester reduction, intramolecular dehydrative cyclizations, hydrazone formation and zeolite induced Fischer-indole synthesis with 53% overall yield. The conditions employed in the present synthesis are mild, efficient and general.
