697287-59-5

Upstream product

• 27144-84-9 2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethylamine 
• 808740-33-2 3-(2-methoxyphenyl)-isoxazole-5-carbaldehyde 
• 29577-53-5 2-Methoxy-benzaldehyde oxime 
• 135-02-4 ortho-anisaldehyde 
• 2252-63-3 1-(4-Fluorophenyl)piperazine 
• 345967-78-4 5-hydroxymethyl-3-(o-methoxyphenyl)isoxazole 
• 923569-52-2 2-(2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers

A small molecule library of piperazinylalkylisoxazole derivatives containing about 600 compounds was designed, synthesized and evaluated for blocking effects on T-type Ca2+ channel. Several ligands were identified to possess high inhibitory activity against the T-type Ca 2+ channel. The compound 21 with trifluoromethyl substituents at C3-position of phenyl group (R1) and C2- position of phenyl group (R2) showed the highest inhibitory activity with IC50 value of 1.02μM, which is comparable to that of mibefradil.