808740-33-2

Usage

Uses

Used in Organic Synthesis:
3-(2-Methoxy-phenyl)-isoxazole-5-carbaldehyde is utilized as a key intermediate in organic synthesis for the preparation of complex organic molecules. Its aldehyde group allows for a range of reactions, making it a valuable component in the construction of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, 3-(2-Methoxy-phenyl)-isoxazole-5-carbaldehyde is employed as a building block for the development of potential pharmaceuticals. 3-(2-METHOXY-PHENYL)-ISOXAZOLE-5-CARBALDEHYDE's structure, including the methoxy and phenyl groups, can influence its interaction with biological targets, thus contributing to its potential as a therapeutic agent.
Used in the Development of Agrochemicals:
3-(2-Methoxy-phenyl)-isoxazole-5-carbaldehyde also finds application in the agrochemical industry. Its specific reactivity and the possibility of fine-tuning its properties through chemical modifications make it a candidate for the development of new pesticides or other agrochemical products.
Used in Chemical Research and Development:
3-(2-METHOXY-PHENYL)-ISOXAZOLE-5-CARBALDEHYDE is also used in academic and industrial research settings to explore new chemical reactions and to develop novel synthetic routes. Its unique structure and reactivity make it a subject of interest for scientists looking to innovate in the field of chemistry.

Upstream product

• 345967-78-4 5-hydroxymethyl-3-(o-methoxyphenyl)isoxazole 
• 135-02-4 ortho-anisaldehyde 
• 29577-53-5 2-Methoxy-benzaldehyde oxime 

Downstream Products

• 697287-61-9 [3-(2-methoxy-phenyl)-isoxazol-5-ylmethyl]-[2-(4-phenyl-piperazin-1-yl)-ethyl]-amine 
• 697287-59-5 {2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethyl}-[3-(2-methoxy-phenyl)-isoxazol-5-ylmethyl]-amine 
• 1337539-56-6 C₂₇H₃₃FN₄O₂ 
• 1337539-50-0 C₂₇H₃₄N₄O₂ 
• 1337539-64-6 C₂₇H₃₃ClN₄O₂ 

Relevant academic research and scientific papers

A rapid and efficient solvent-free microwave-assisted synthesis of pyrazolone derivatives containing substituted isoxazole ring

An efficient synthesis of 4-substituted pyrazolone derivatives was developed. 4-Substituted pyrazolone derivatives were synthesized in 78-97% yields starting from various 3-substituted isoxazole-5-carbaldehydes, ethyl acetoacetate and hydrazine under micr

An efficient solvent-free synthesis of isoxazolyl-1,4-dihydropyridines on solid support SiO2 under microwave irradiation

An efficient synthesis of 1,4-dihydropyridines was developed. 1,4-Dihydropyridines were synthesized starting from various 3-substituted isoxazolyl-5-carbaldehydes, ethyl acetoacetate, and ammonium acetate under microwave irradiation and solvent-free conditions (86–96?%), and were characterized by HRMS, FT-IR, 1H NMR, and 13C NMR spectroscopy. Solid support SiO2 was found to possess favorable catalysis and dispersancy for the condensation reaction. The merits of the method included the environmental friendly reaction conditions, simple operation, extensive substrates, good yields and reuse of the SiO2. Moreover, the crystal structure of compound diethyl 4-[3-(2-methoxyphenyl)isoxazol-5-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate in orthorhombic Pbca space group was presented. Graphical abstract: [Figure not available: see fulltext.]

Efficient solvent-free synthesis of bis(indolyl)methanes on SiO2 solid support under microwave irradiation

An efficient synthesis of bis(indolyl)methanes was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85-98 %). Solid support SiO2 was found to possess favorable catalytic and dispersancy parameters for the condensation reaction. Moreover, novel bis(indolyl)methanes containing an isoxazole ring were synthesized via this method in excellent yields (> 94 %) using 3-substituted isoxazole-5-carbaldehydes and indole.

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers

A small molecule library of piperazinylalkylisoxazole derivatives containing about 600 compounds was designed, synthesized and evaluated for blocking effects on T-type Ca2+ channel. Several ligands were identified to possess high inhibitory activity against the T-type Ca 2+ channel. The compound 21 with trifluoromethyl substituents at C3-position of phenyl group (R1) and C2- position of phenyl group (R2) showed the highest inhibitory activity with IC50 value of 1.02μM, which is comparable to that of mibefradil.