697300-68-8 Usage
Uses
Used in Pharmaceutical Research:
6-BROMO-5-IODOPYRIDIN-3-AMINE is utilized as a key intermediate in the synthesis of various biologically active molecules, contributing to the development of novel drugs and pharmaceuticals. Its unique structural features and reactivity make it a valuable component in medicinal chemistry for the design and synthesis of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 6-BROMO-5-IODOPYRIDIN-3-AMINE is employed as a building block for the creation of complex organic molecules. Its presence in the synthesis process can lead to the formation of compounds with specific biological activities or desired chemical properties.
Used in Materials Science:
6-BROMO-5-IODOPYRIDIN-3-AMINE is used as a component in the development of new materials, leveraging its unique properties to contribute to the advancement of material science. Its versatility in chemical reactions allows for the exploration of its potential in creating materials with specific characteristics for various applications.
Used in Agrochemical Research:
In agrochemical research, 6-BROMO-5-IODOPYRIDIN-3-AMINE is applied as a starting material or intermediate in the synthesis of agrochemicals. Its unique chemical properties may contribute to the development of new pesticides, herbicides, or other agrochemicals that can improve agricultural productivity and crop protection.
Check Digit Verification of cas no
The CAS Registry Mumber 697300-68-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,7,3,0 and 0 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 697300-68:
(8*6)+(7*9)+(6*7)+(5*3)+(4*0)+(3*0)+(2*6)+(1*8)=188
188 % 10 = 8
So 697300-68-8 is a valid CAS Registry Number.
697300-68-8Relevant academic research and scientific papers
5-Substituted Derivatives of 6-Halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-Halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with Low Picomolar Affinity for α4β2 Nicotinic Acetylcholine Receptor and Wide Range of Lipophilicity: Potential Probes for Imaging with Positron Emission Tomography
Zhang, Yi,Pavlova, Olga A.,Chefer, Svetlana I.,Hall, Andrew W.,Kurian, Varughese,Brown, LaVerne L.,Kimes, Alane S.,Mukhin, Alexey G.,Horti, Andrew G.
, p. 2453 - 2465 (2007/10/03)
Potential positron emission tomography (PET) ligands with low picomolar affinity at the nicotinic acetylcholine receptor (nAChR) and with lipophilicity (log D) ranging from - 1.6 to +1.5 have been synthesized. Most members of the series, which are derivatives of 5-substituted-6-halogeno-A-85380, exhibited a higher binding affinity at α4β2-nAChRs than epibatidine. An analysis, by molecular modeling, revealed an important role of the orientation of the additional heterocyclic ring on the binding affinity of the ligands with nAChRs. The existing nicotinic pharmacophore models do not accommodate this finding. Two compounds of the series, 6-[18F]fluoro-5-(pyridin-3-yl)-A-85380 ([18F]31) and 6-chloro-3-((2-(S)-azetidinyl)methoxy)-5-(2-[ 18F]fluoropyridin-5-yl)pyridine) ([18F]35), were radiolabeled with 18F. Comparison of PET data for [18F]31 and 2-[18F]FA shows the influence of lipophilicity on the binding potential. Our recent PET studies with [18F]35 demonstrated that its binding potential values in Rhesus monkey brain were ca. 2.5 times those of 2-[18F]FA. Therefore, [18F]35 and several other members of the series, when radiolabeled, will be suitable for quantitative imaging of extrathalamic nAChRs.
