697300-72-4 Usage
Uses
Used in Organic Synthesis:
3-Bromo-2-fluoro-5-iodopyridine is used as a key intermediate in organic synthesis for the creation of various complex organic molecules. Its unique combination of halogen substituents allows for selective reactions and functional group transformations, facilitating the synthesis of diverse chemical entities.
Used in Pharmaceutical Research:
In pharmaceutical research, 3-Bromo-2-fluoro-5-iodopyridine serves as a valuable building block for the development of new molecules with potential therapeutic applications. Its structural features can be exploited to design and synthesize novel drug candidates with improved pharmacological properties, such as enhanced potency, selectivity, and bioavailability.
Used in the Production of Pharmaceuticals:
3-Bromo-2-fluoro-5-iodopyridine has the potential to be utilized in the production of pharmaceuticals, particularly those targeting specific diseases or conditions. Its incorporation into drug molecules can contribute to the discovery of new therapeutic agents with unique mechanisms of action and improved efficacy.
Used in the Production of Agrochemicals:
Similarly, 3-Bromo-2-fluoro-5-iodopyridine can be employed in the development of agrochemicals, such as pesticides and herbicides. Its reactivity and structural diversity enable the creation of novel compounds with targeted activity against pests or weeds, potentially leading to more effective and environmentally friendly agricultural solutions.
However, it is important to note that 3-Bromo-2-fluoro-5-iodopyridine is a highly reactive compound and should be handled with caution due to its potential health hazards. Proper safety measures and handling protocols must be followed to minimize risks associated with its use in research and industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 697300-72-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,7,3,0 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 697300-72:
(8*6)+(7*9)+(6*7)+(5*3)+(4*0)+(3*0)+(2*7)+(1*2)=184
184 % 10 = 4
So 697300-72-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H2BrFIN/c6-4-1-3(8)2-9-5(4)7/h1-2H
697300-72-4Relevant academic research and scientific papers
5-Substituted Derivatives of 6-Halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-Halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with Low Picomolar Affinity for α4β2 Nicotinic Acetylcholine Receptor and Wide Range of Lipophilicity: Potential Probes for Imaging with Positron Emission Tomography
Zhang, Yi,Pavlova, Olga A.,Chefer, Svetlana I.,Hall, Andrew W.,Kurian, Varughese,Brown, LaVerne L.,Kimes, Alane S.,Mukhin, Alexey G.,Horti, Andrew G.
, p. 2453 - 2465 (2007/10/03)
Potential positron emission tomography (PET) ligands with low picomolar affinity at the nicotinic acetylcholine receptor (nAChR) and with lipophilicity (log D) ranging from - 1.6 to +1.5 have been synthesized. Most members of the series, which are derivatives of 5-substituted-6-halogeno-A-85380, exhibited a higher binding affinity at α4β2-nAChRs than epibatidine. An analysis, by molecular modeling, revealed an important role of the orientation of the additional heterocyclic ring on the binding affinity of the ligands with nAChRs. The existing nicotinic pharmacophore models do not accommodate this finding. Two compounds of the series, 6-[18F]fluoro-5-(pyridin-3-yl)-A-85380 ([18F]31) and 6-chloro-3-((2-(S)-azetidinyl)methoxy)-5-(2-[ 18F]fluoropyridin-5-yl)pyridine) ([18F]35), were radiolabeled with 18F. Comparison of PET data for [18F]31 and 2-[18F]FA shows the influence of lipophilicity on the binding potential. Our recent PET studies with [18F]35 demonstrated that its binding potential values in Rhesus monkey brain were ca. 2.5 times those of 2-[18F]FA. Therefore, [18F]35 and several other members of the series, when radiolabeled, will be suitable for quantitative imaging of extrathalamic nAChRs.
