69737-80-0Relevant academic research and scientific papers
Preparation method and application of N-(N-trifluoromethyl imino acyl) pyridinium salt
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, (2022/04/06)
The invention discloses N-(N-trifluoromethyl imino acyl) pyridinium salt and a preparation method and application thereof, and belongs to the technical field of organic synthetic chemistry, wherein after N-trifluoromethylation of nitrile molecules, 4-dimethylamino pyridine is added, and the N-(N-trifluoromethyl imino acyl) pyridinium salt can be rapidly obtained. The N-(N-trifluoromethyl imino acyl) pyridinium salt prepared by the invention can react with N-, O- and S- nucleophiles to synthesize N-CF3 amidine and N-(N-CF3 imino acyl) N heterocyclic ring, N-CF3 imino acid ester and N-CF3 thioimino acid ester respectively, and can react with 1, 3 dipoles to synthesize N-CF3 tetrazole, N-CF3 imidazole, N-CF3 triazole, the defects of low yield, poor substrate universality, harsh reaction conditions, use of expensive and dangerous chemical reagents and the like in the synthesis of the N-CF3-containing compound in the prior art are overcome.
