69739-16-8

Basic information

• Product Name: Cefodizime
• Synonyms: CEFODIZIME;Cefodizime,CDZM;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-, (6R,7R)-;7-(α-(Z)-Methoxyimino-α-(2-aminothiazol-4-yl)acetamido)-3-((5-carboxymethyl-4-methylthiazol-2-yl)thiomethyl)-3-cephem-4-carboxylic acid;7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((5-(carboxymethyl)-4-methyl-2-thiazolyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid;FIR-221;Cefodizme;CefodizMe SodiuM
• CAS NO: 69739-16-8
• Molecular Formula: C₂₀H₂₀N₆O₇S₄
• Molecular Weight: 584.67
• EINECS: 1592732-453-0
• Product Categories: Pharmaceutical intermediate
• Mol File: 69739-16-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.869 g/cm³
• Refractive Index: 1.851
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: pK1 2.85; pK2 3.37; pK3 4.18(at 25℃)
• CAS DataBase Reference: Cefodizime(CAS DataBase Reference)
• NIST Chemistry Reference: Cefodizime(69739-16-8)
• EPA Substance Registry System: Cefodizime(69739-16-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-42/43
• Safety Statements: 22-26-36/37/39
• Hazardous Substances Data: 69739-16-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 69739-16-8 differently. You can refer to the following data:
1. Cefodizime is a third generation cephalosporin with a broad spectrum of antibacterial activity. Cefodizime maybe useful in the treatment of otitis media, sinusitis and gynaecological infections, and f or the prophylaxis or treatment of surgical infections.
2. Cefodizime is a third generation cephalosporin with a broad spectrum of antibacterial activity. Cefodizime maybe useful in the treatment of otitis media, sinusitis and gynaecological infections, and for the prophylaxis or treatment of surgical infections.

Definition

ChEBI: A cephalosporin compound having 5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively.

InChI:InChI=1/C20H20N6O7S4/c1-7-10(3-11(27)28)37-20(22-7)36-5-8-4-34-17-13(16(30)26(17)14(8)18(31)32)24-15(29)12(25-33-2)9-6-35-19(21)23-9/h6,13,17H,3-5H2,1-2H3,(H2,21,23)(H,24,29)(H,27,28)(H,31,32)/b25-12+/t13-,17-/m1/s1

Upstream product

• 86329-79-5 Kenicef 

Relevant articles and documents

NOVEL INTERMEDIATES FOR SYNTHESIS OF CEPHALOSPORINS AND PROCESS FOR PREPARATION OF SUCH INTERMEDIATES

A novel 4-halo-2-oxyimino-3-oxo butyric acid-N, N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics, wherein X is chlorine or bromine; R is hydrogen, C1-4 alkyl group, an easily removable hydroxyl protective group, -CH2COOR5, or -C(CH3)2COOR5, wherein R5 is hydrogen or an easily hydrolysable ester group. The compound of formula (I) is prepared by reacting 4-halo-2-oxyimino-3-oxobutyric acid of formula (IV1), wherein X, R and R5 are as defined above, with N, N-dimethylformiminium chloride chlorosulphate of formula (VII), in an organic solvent at a temperature ranging from -30 °C to -15 °C. The cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, cefquinome, ceftazidime, cefteram pivoxil, ceftiofur, ceftizoxime, ceftriaxone and cefuzonam.

Alkaline and neutral degradation of cefodizime (THR-221) and structural elucidation of the products. II

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