69739-62-4

Usage

Uses

Used in Pharmaceutical Industry:
6-CHLORO-1,2-DIHYDRO-NAPHTHALENE is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 6-CHLORO-1,2-DIHYDRO-NAPHTHALENE is used as a precursor in the production of agrochemicals, such as pesticides and herbicides, to enhance crop protection and yield.
Used in Dye Industry:
6-CHLORO-1,2-DIHYDRO-NAPHTHALENE is utilized as a building block in the synthesis of dyes, contributing to the creation of a wide range of colorants for various applications, including textiles, plastics, and printing inks.
Used in Research Chemicals:
As a research chemical, 6-CHLORO-1,2-DIHYDRO-NAPHTHALENE is employed in laboratory settings for various organic synthesis reactions, aiding scientists in the discovery and development of new chemical compounds and processes.

Upstream product

• 26673-32-5 7-chloro-3,4-dihydro-2H-naphthalen-1-one 
• 69739-61-3 (±)-7-chloro-1,2,3,4-tetrahydronaphthalen-1-ol 
• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 4619-18-5 4-(4-chlorophenyl)butanoic acid 
• 108-90-7 chlorobenzene 

Downstream Products

• 91-58-7 2-chloronaphthalene 

Relevant academic research and scientific papers

Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles

Bromodomain and extra-terminal domain (BET) inhibitors are widely used both as chemical tools to study the biological role of their targets in living organisms and as candidates for drug development against several cancer variants and human disorders. However, non-BET bromodomains such as those in p300 and CBP are less studied. XDM-CBP is a highly potent and selective inhibitor for the bromodomains of CBP and p300 derived from a pan-selective BET BRD-binding fragment. Along with X-ray crystal-structure analysis and thermodynamic profiling, XDM-CBP was used in screenings of several cancer cell lines in vitro to study its inhibitory potential on cancer cell proliferation. XDM-CBP is demonstrated to be a potent and selective CBP/p300 inhibitor that acts on specific cancer cell lines, in particular malignant melanoma, breast cancer, and leukemia.

Catalytic asymmetric intermolecular bromoesterification of unfunctionalized olefins

An asymmetric intermolecular bromoesterification of unfunctionalized olefins catalyzed by (DHQD)2PHAL is described. Optically active bromoesters can be obtained with up to 92% ee.

Intramolecular Aromatic Cyclizations of Alkenyliodonium Tetrafluoroborates

1,2-Dihydronaphthalene and 2H-chromene derivatives have been synthesized by thermal intramolecular cyclizations of alkenyliodonium tetrafluoroborates under mild reaction conditions.