6974-50-1

Usage

Uses

Used in Pharmaceutical Industry:
(Ethylsulfonyl-phenyl-methyl)benzene is used as an intermediate for the synthesis of various pharmaceuticals. Its complex molecular structure allows for the creation of diverse medicinal compounds, contributing to the development of new drugs and treatments.
Used in Dye Industry:
In the dye industry, (ethylsulfonyl-phenyl-methyl)benzene serves as a crucial component in the production of different types of dyes. Its chemical properties enable the creation of a wide range of colors and hues, enhancing the dye manufacturing process.
Used in Organic Chemical Products:
(Ethylsulfonyl-phenyl-methyl)benzene is also utilized in the production of other organic chemical products, highlighting its versatility and importance in the chemical industry.
Used in Fragrance Industry:
Leveraging its strong aromatic properties, (ethylsulfonyl-phenyl-methyl)benzene is used as a component in the fragrance industry. It contributes to the creation of various scents and perfumes, adding to the complexity and richness of the final product.
Safety Precautions:
It is essential to handle (ethylsulfonyl-phenyl-methyl)benzene with care, as it may pose health and environmental hazards if not properly managed. Proper safety measures should be taken to minimize risks during its production, use, and disposal.

Upstream product

• 38793-64-5 benzhydryl ethyl sulfide 
• 90-99-3 diphenylchloromethane 
• 74-96-4 ethyl bromide 
• 4237-48-3 diphenylmethanethiol 

Downstream Products

• 54160-30-4 1-(3-ethanesulfonyl-1-methyl-3,3-diphenyl-propyl)-piperidine 
• 102321-34-6 (3-ethanesulfonyl-3,3-diphenyl-propyl)-dimethyl-amine; hydrochloride 
• 102759-39-7 diethyl-(3-ethanesulfonyl-3,3-diphenyl-propyl)-amine; hydrochloride 
• 114538-73-7 (-)-(3-ethanesulfonyl-1-methyl-3,3-diphenyl-propyl)-dimethyl-amine 
• 114538-73-7 (+)-(3-ethanesulfonyl-1-methyl-3,3-diphenyl-propyl)-dimethyl-amine 
• 114538-73-7 (+/-)-(3-ethanesulfonyl-1-methyl-3,3-diphenyl-propyl)-dimethyl-amine 
• 54160-29-1 1-(3-ethanesulfonyl-3,3-diphenyl-propyl)-piperidine 
• 101-81-5 Diphenylmethane 

Relevant academic research and scientific papers

Photosensitized electron transfer oxidation of sulfides: A steady-state study

The photosensitized electron-transfer oxidation of a series of ethyl sulfides RSEt (1, R = C12H25; 2, PhCH2CH 2; 3, PhCH2; 4, PhCMe2; 5, Ph2CH) has been examined in acetonitrile and the product distribution discussed on the basis of the mechanisms proposed. In nitrogen-flushed solutions, cleaved alcohols and alkenes are formed, whereas under oxygen, in reactions that are 10-70 times faster, sulfoxides and cleaved aldehydes and ketones are formed in addition to the afore-mentioned products. Two sensitizers are compared, 9,10-dicyanoanthracene (DCA) and 2,4,6-triphenylpyrylium tetrafluoroborate (TPP+BF4-), the former giving a higher proportion of the sulfoxide, the latter of cleaved carbonyls. The sulfoxidation is due to the contribution of the singlet oxygen path with DCA. Oxidative cleavage, on the other hand, occurs both with DCA and with TPP+ which is known to produce neither singlet oxygen nor the superoxide anion. This process involves deprotonation from the α position of the sulfide radical cation, but the TPP+ results suggest that O2.- is not necessarily involved and non-activated oxygen forms a weak adduct with the radical cation promoting α-hydrogen transfer, particularly with benzylic derivatives. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

The photooxygenation of benzyl, heteroarylmethyl, and allyl sulfides

The photosensitised oxidation of benzyl ethyl sulfides in aprotic solvents (benzene or acetonitrile) gives the corresponding aldehydes under mild conditions. This is a general reaction which applies to benzyl derivatives containing either electron-donating or electron-withdrawing substituents and furthermore to hereto analogues such as 2-pyridinylmethyl sulfide (not to the 3-indolylmethyl sulfide, since reaction at the heterocycle moiety competes) as well as to allyl sulfides. In a protic solvent (methanol) these sulfides give the sulfoxides instead (except for the nitrobenzyl derivatives, where the aldehyde remains the major product). Among the α-substituted sulfides tested, the α-phenylbenzyl and the 3- cyclohexenyl sulfide give the corresponding ketone (the latter in a low yield), but the α-methylbenzyl sulfide gives the sulfoxide as the main product. The rate for singlet oxygen quenching and for chemical reaction have been measured for representative benzyl sulfides. The reaction is discussed in the frame of the currently accepted mechanism for sulfide photooxygenation. The key step for oxidative C-S bond cleavage appears to be hydrogen transfer from the activated α position in the first formed intermediate, the persulfoxide. This reaction is inhibited in methanol where the persulfoxide is hydrogen-bonded.

Photosensitized oxygenation of some benzyl sulfides. The role of persulfoxide

Benzyl ethyl sulfide (6a) is photo-oxidized to benzaldehyde in benzene, whereas diethyl sulfide is known to give inefficiently the sulfoxide under these conditions. Oxidative C-S cleavage is the main process also with benzhydryl ethyl sulfide (6c), but not with α-methylbenzyl ethyl sulfide (6b), which mainly gives the sulfoxide. The carbonyl derivatives reasonably arise from S-hydroperoxy ylides (3). Consistently with this finding, calculations at the PM3 level suggest that the first intermediate, the persulfoxide (1), undergoes intramolecular hydrogen transfer when an activated α-hydrogen is available and gives 3. This is the case for the above benzyl sulfides (ΔH* for the process decreases with decreasing C-H BDE). However, only some of the persulfoxide conformations are correctly oriented for this rearrangement, and this may slow this process and make other reactions compete, as happens with 6b. Copyright