6974-56-7

Basic information

• Product Name: 2-CHLORO-N-(2,4-DICHLOROPHENYL)ACETAMIDE
• Synonyms: AKOS B015623;AKOS BBS-00004005;2-CHLORO-N-(2,4-DICHLOROPHENYL)ACETAMIDE;ART-CHEM-BB B015623;N-CHLOROACETYL-2,4-DICHLOROANILINE;N1-(2,4-DICHLOROPHENYL)-2-CHLOROACETAMIDE;Acetamide,2-chloro-N-(2,4-dichlorophenyl)-;Acetanilide,2,2’,4’-trichloro-
• CAS NO: 6974-56-7
• Molecular Formula: C₈H₆Cl₃NO
• Molecular Weight: 238.5
• Mol File: 6974-56-7.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 385.1 °C at 760 mmHg
• Flash Point: 186.7 °C
• Appearance: /
• Density: 1.511 g/cm³
• Vapor Pressure: 3.9E-06mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CHLORO-N-(2,4-DICHLOROPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-(2,4-DICHLOROPHENYL)ACETAMIDE(6974-56-7)
• EPA Substance Registry System: 2-CHLORO-N-(2,4-DICHLOROPHENYL)ACETAMIDE(6974-56-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 6974-56-7(Hazardous Substances Data)

Usage

General Description

2-Chloro-N-(2,4-dichlorophenyl)acetamide is a chemical compound with the molecular formula C8H6Cl3NO. 2-CHLORO-N-(2,4-DICHLOROPHENYL)ACETAMIDE includes chlorine atoms providing it the unique properties attributed to chlorinated compounds. It falls into the category of organic compounds known as benzene and substituted derivatives, meaning it has a benzene core structure, one of the most commonly occurring structures in organic chemistry, which is substituted with other functional groups. As an organic amide, it is a class of compound that contains a carbonyl (C=O) group attached to a nitrogen atom. Its physical properties, potential uses, or biological effects largely depend on its structure and functional groups. Specific information about this compound including its biological effects, potential hazards, or uses is limited, implying it may not be widely used or studied.

InChI:InChI=1/C8H6Cl3NO/c9-4-8(13)12-7-2-1-5(10)3-6(7)11/h1-3H,4H2,(H,12,13)

Upstream product

• 587-65-5 N-chloroacetyl-aniline 
• 4015-58-1 monochloroacetic acid anhydride 
• 554-00-7 2,4-Dichloroaniline 
• 71-43-2 benzene 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 92106-50-8 <2-Amino-4-chlor-phenylmercapto>-essigsaeure-<2,4-dichloranilid> 
• 92436-27-6 (2-Carbamoyl-phenylmercapto)-essigsaeure-(2,4-dichlor-anilid) 
• 398136-85-1 3-amino-N-(2,4-dichlorophenyl)-6-methoxybenzofuran-2-carboxamide 
• 1310561-76-2 N-(2,4-dichlorophenyl)-2-(4-((4,6-dioxo-2-thioxotetrahydropyrimidin-5(6H)-ylidene)methyl)phenoxy)acetamide 
• 1310561-63-7 N-(2,4-dichlorophenyl)-2-(4-((2,4,6-trioxotetrahydropyrimidin-5(6H)-ylidene)methyl)phenoxy)acetamide 
• 1352228-97-7 C₁₈H₁₂Cl₃N₃OS 
• 39190-19-7 N-(2,4-dichlorophenyl)benzo[d]oxazol-2-amine 

Relevant articles and documents

Triazole sulfonamides derivatives and their use in agriculture

The invention provides a novel triazole sulfonamide derivative and application thereof in agriculture. , The invention relates to a triazole sulfonamides derivative as shown in a formula (I) and a preparation method thereof. I In formula (R)1 And R2 Are each independently hydrogen. C1 -6 Alkyl and the like, R3 Document C3 -8 Cycloalkyl, R4 -SO2 - NRa Rb , SO2 - C1 -6 Alkyl group, SO2 - C3 -8 Cycloalkyl, SO2 - C1 -3 Alkylene - C3 -8 Cycloalkyl, SO2 - Rc , C1 -3 Alkylene - C (＝ O) O-C1 -6 Alkyl or - C1 -3 Alkylene - C (＝ O) - NRd Re , Ra , Rb , Rc , Rd And Re Having the meaning of the invention. The compound, the composition containing the compound and/or the preparation provided by the invention has good bactericidal activity and can be used as a bactericide in agriculture.

Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities

Aiming to obtain an efficient anti-proliferative activity, structure- and ligand-based drug design approaches were expanded and utilized to design and refine a small compound library. Subsequently, thirty-two 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives were selected for synthesis based on the characteristic pharmacophoric features required for PI3K and B-Raf oncogenes inhibition. All the synthesized compounds were evaluated for their in vitro anticancer activity. Compounds 17 and 22c displayed an acceptable potent activity according to the DTP-NCI and were further evaluated in the NCI five doses assay. To validate our design, compounds with the highest mean growth inhibition percent were screened against the target PI3Kα and B-RafV600E to confirm their multi-kinase activity. The tested compounds showed promising multi-kinase activity. Compounds 17 and 22c anticancer effectiveness and multi-kinase activity against PI3Kα and B-RafV600E were consolidated by the inhibition of B-RafWT, EGFR and VEGFR-2 with IC50 in the sub-micromolar range. Further investigations on the most potent compounds 17 and 22c were carried out by studying their safety on normal cell line, in silico profiling and predicted ADME characteristics.

Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway

In order to find new and highly effective anti-tumor drugs with targeted therapeutic effects, a series of novel 4-aminoquinazoline derivatives containing N-phenylacetamide structure were designed, synthesized and evaluated for antitumor activity against four human cancer cell lines (H1975, PC-3, MDA-MB-231 and MGC-803) using MTT assay. The results showed that the compound 19e had the most potent antiproliferative activity against H1975, PC-3, MDA-MB-231 and MGC-803 cell lines. At the same time, compound 19e could significantly inhibit the colony formation and migration of H1975 cells. Compound 19e also arrested the H1975 cell cycle in the G1 phase and mediated cell apoptosis, promoted the accumulation of ROS in H1975 cells. Furthermore, compound 19e exerted antitumor effect in vitro by reducing the expression of anti-apoptotic protein Bcl-2 and increasing the pro-apoptotic protein Bax and p53. Mechanistically, compound 19e could significantly decreased the phosphorylation of EGFR and its downstream protein PI3K in H1975 cells. Which indicated that compound 19e targeted H1975 cell via interfering with EGFR-PI3K signaling pathway. Molecular docking showed that compound 19e could bind into the active pocket of EGFR. Those work suggested that compound 19e would have remarkable implications for further design of anti-tumor agents.