303014-69-9

Basic information

• Product Name: (S)-8-Bromo-3-[2-hydroxy-3-(trityloxy)propyl]adenine
• Synonyms: (S)-8-Bromo-3-[2-hydroxy-3-(trityloxy)propyl]adenine
• CAS NO: 303014-69-9
• Molecular Weight: 530.424
• Mol File: 303014-69-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-8-Bromo-3-[2-hydroxy-3-(trityloxy)propyl]adenine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-8-Bromo-3-[2-hydroxy-3-(trityloxy)propyl]adenine(303014-69-9)
• EPA Substance Registry System: (S)-8-Bromo-3-[2-hydroxy-3-(trityloxy)propyl]adenine(303014-69-9)

Safety Data

• Hazardous Substances Data: 303014-69-9(Hazardous Substances Data)

Upstream product

• 66224-66-6 adenine 
• 6974-78-3 8-bromoadenine 
• 129940-50-7 (S)-tritylglycidol 

Downstream Products

• 169776-86-7 (S)-8-Bromo-3-(2,3-dihydroxypropyl)adenine 

Relevant articles and documents

Synthesis of acyclic nucleoside and nucleotide analogs derived from 6-amino-7H-purin-8(9H)-one

Reaction of 8-bromoadenine derivatives 2 with sodium acetate in acetic acid and cleavage of (S)-7-[(trityloxy)methyl]-7,8-dihydro[1,3]oxazolo[3,2-e]purin-4-amine (12) and diisopropyl (S)-[[(4-amino-8,9-dihydro-7H-[1,3]oxazino[3,2-e]purin-8-yl)oxy]methyl]phosphona te (13a) were used for the synthesis of the corresponding N9-substituted derivatives of 6-amino-7H-purin-8(9H)-one 3a-3c and 7. Alkylation of 6-amino-7H-purin-8(9H)-one (3a) with diverse alkylation agents afforded the title N9-monosubstituted 3b, 3d and 7a and N7,N9-disubstituted acyclic nucleoside and nucleotide analogs 6b, 6d and 8a.