69775-51-5

Upstream product

• 37464-90-7 5,8-dimethoxy-2-tetralone 
• 58851-64-2 6,7-epoxy-5,6,7,8-tetrahydro-1,4-dimethoxynaphthalene 
• 143325-80-8 N-oxide of trans-3-(N-hydroxyethyl-N-methylamino)-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol 
• 143406-79-5 (2S,3S)-3-[(2-Hydroxy-ethyl)-methyl-amino]-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol; hydrochloride 
• 69031-41-0 2-ethoxy-5,8-dimethoxy-1,4-dihydro-naphthalene 
• 66947-66-8 (+/-)-6-ethoxy-(4ar,8ac)-4a,5,8,8a-tetrahydro-[1,4]naphthoquinone 
• 858458-53-4 3-ethoxy-5,8-dimethoxy-1,2-dihydro-naphthalene 
• 106-51-4 p-benzoquinone 

Downstream Products

• 37464-90-7 5,8-dimethoxy-2-tetralone 

Relevant academic research and scientific papers

THE SYNTHESIS AND IDENTIFICATION OF ISOMERIC PRODUCTS OF ENZYMATIC O-DEMETHYLATION OF THE SYMPATHOMIMETIC TETRAMINOL - trans-3-(2-HYDROXYETHYLAMINO)-5,8-DIMETHOXY-1,2,3,4-TETRAHYDRO-2-NAPHTHOL

The structure of the positional isomers of mono-O-demethylated metabolites (V and VI) of Tetraminol - trans-3-(2-hydroxyethylamino)-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol (XIX) - and the pairs of related derivatives was determined.

P-aminophenols, derivatives thereof and method of use

p-Aminophenols are provided having the structure STR1 wherein m is 0, 1 or 2; n is 0, 1, 2 or 3; R1 and R2 may be the same or different and are H, hydroxy or alkoxy; R3 is H, lower alkyl, alkanoyl or aroyl and R4 is H, lower alkyl or alkanoyl, and including acid-addition salts thereof. These compounds are useful as inhibitors of leukotriene production and as such are useful as antiallergy, anti-inflammatory and anti-psoriatic agents.

8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists

A series of 2-(alkylamino)tetralins related to 8-hydroxy-2-(di-n-propylamino)tetralin (21) were prepared and tested as dopamine (DA) and 5-hydroxytryptamine (5-HT) receptor agonists. Several of the compounds were potent 5-HT agonists devoid of DA-mimetic effects. N-Ethyl or N-propyl substitution of 8-hydroxy-2-aminotetralin gave the most potent agonists. It was shown that the most potent compound, (+)-21, has the 2R configuration. 5,8-Dimethoxy-2-(di-n-propylamino)tetralin (31) was found to be a weak DA agonist devoid of 5-HT activity. The corresponding indan derivative, 4,7-dimethoxy-2-(di-n-propylamino)indan (39), has been reported to be active on both DA and 5-HT receptors. The 5-HT-stimulating properties of compounds 21 and 39 as compared to the incapability of compound 31 to activate the 5-HT receptor is tentatively explained by the assumed mode of binding of the compounds to the 5-HT receptor.