697751-91-0

Upstream product

• 27372-03-8 ethyl anti-(2R,3R)-2-methyl-3-hydroxybutanoate 
• 697751-89-6 (2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-butyric acid ethyl ester 
• 697751-90-9 (E)-(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-2-enoic acid methyl ester 

Downstream Products

• 174156-40-2 (E)-(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-2-enal 
• 174156-41-3 (E)-(2R,3S,6S,7R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,6-dimethyl-oct-4-enoic acid methyl ester 
• 174156-45-7 Acetic acid (3E,15E)-(1R,2S,5S,6R,10S,12R,14S)-14-(tert-butyl-dimethyl-silanyloxy)-16-ethyl-5-(4-methoxy-benzyloxy)-1,2,6,10,12-pentamethyl-7-oxo-octadeca-3,15,17-trienyl ester 
• 174156-46-8 Benzoic acid (3E,15E)-(1R,2S,5S,6R,10S,12R,14S)-14-(tert-butyl-dimethyl-silanyloxy)-16-ethyl-5-(4-methoxy-benzyloxy)-1,2,6,10,12-pentamethyl-7-oxo-octadeca-3,15,17-trienyl ester 

Relevant academic research and scientific papers

The first enantioselective synthesis of the amino acid, (2S,3S,4R)-γ-hydroxyisoleucine using a palladium(ii) catalysed 3,3-sigmatropic rearrangement

A synthetic route towards the synthesis of (2S,3S,4R)-γ- hydroxyisoleucine, the amino acid component of the natural product, funebrine has been developed using as the key step, a palladium(II) catalysed 3,3-sigmatropic rearrangement to create the (2S)-stereogenic centre.

Determination of the C-7,9,12,13,17 and 18 stereochemistries of tautomycetin. Synthesis of the tautomycetin degradation product

Syntheses of the degradation product 3 of tautomycetin (1) and its diastereoisomers have been achieved. Comparison of the spectral data of these diastereoisomers with those of the degradation product of natural 1 indicates that tautomycetin has the 7R,9S,12S,13S,17S,18R stereochemistry.