698-25-9

Basic information

• Product Name: 6-CHLORO (1H)INDAZOLE
• Synonyms: 1H-Indazole, 6-chloro-;6-Chloro-1H-indazole, >95%;BUTTPARK 121\04-74;6-CHLORO (1H)INDAZOLE;6-CHLOROINDAZOLE;6-chloro-1H-indazole(WXC03625)
• CAS NO: 698-25-9
• Molecular Formula: C₇H₅ClN₂
• Molecular Weight: 152.58
• Product Categories: pharmacetical
• Mol File: 698-25-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 174-177℃
• Boiling Point: 309.5 °C at 760 mmHg
• Flash Point: 169.9 °C
• Appearance: /
• Density: 1.425 g/cm³
• Vapor Pressure: 0.00116mmHg at 25°C
• Refractive Index: 1.703
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.82±0.40(Predicted)
• CAS DataBase Reference: 6-CHLORO (1H)INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO (1H)INDAZOLE(698-25-9)
• EPA Substance Registry System: 6-CHLORO (1H)INDAZOLE(698-25-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 698-25-9(Hazardous Substances Data)

Usage

Application

6-Chloro-1H-indazole is a useful research chemical.

InChI:InChI=1/C7H5ClN2/c8-6-2-1-5-4-9-10-7(5)3-6/h1-4H,(H,9,10)

Upstream product

• 95-79-4 5-chloro-2-methyl-benzenamine 
• 108-24-7 acetic anhydride 
• 84459-33-6 2-bromo-4-chlorobenzaldehyde 
• 2420-26-0 4-chlorosalicylaldehyde 
• 61072-56-8 4-chloro-2-fluorobenzaldehyde 
• 708-40-7 1-Acetyl-6-chlorindazol 

Downstream Products

• 1350852-88-8 4-amino-2-[6-chloro-1-(3,3,4,4,4-pentafluorobutyl)-1H-indazol-3-yl]-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one 
• 885278-30-8 6-chloro-1H-indazole-3-carbonitrile 
• 1350854-36-2 2-[6-chloro-1-(3,3,4,4,4-pentafluorobutyl)-1H-indazol-3-yl]-5-methyl-4-(methylamino)-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one 
• 1350856-26-6 4-bromo-2-[6-chloro-1-(3,3,4,4,4-pentafluorobutyl)-1H-indazol-3-yl]-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one 
• 717134-47-9 methyl 6-chloro-1H-indazole-3-carboxylate 
• 503045-59-8 6-chloro-3-iodo-1H-indazole 
• 1339955-99-5 4-[6-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl]piperazin-1-carboxylic acid benzyl ester 

Relevant articles and documents

A novel copper-catalyzed, hydrazine-free synthesis of N-1 unsubstituted 1H-indazoles using stable guanylhydrazone salts as substrates

A CuI-catalyzed, hydrazine-free transformation of 2-(2-bromoarylidene)guanylhydrazone hydrochlorides using Cs2CO3 as a base and DMEDA as a ligand at 120 °C for 5 h delivers substituted 1H-indazoles with yields up to 75%. The C,N double bond configuration of the substrates was determined by NMR experiments and quantum chemical calculations. The reaction mechanism was studied using quantum chemical calculations.

SOLUBLE GUANYLATE CYCLASE STIMULATORS

The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R4, Ra, and the subscripts m, p, and q are as described herein. The compounds or their

ALPHA 7 NICOTINIC ACETYLCHOLINE ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF

The present application is related to compounds represented by Formula I, which are novel positive allosteric modulators of al nAChRs. The application also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on al nAChRs in a mammal by administering an effective amount of a compound of Formula I.