717134-47-9

Usage

Uses

Used in Pharmaceutical Development:
METHYL 6-CHLORO-1H-INDAZOLE-3-CARBOXYLATE is used as a key intermediate in the synthesis of new drugs due to its ability to be incorporated into various complex organic compounds. Its unique molecular structure allows for the development of pharmaceuticals with potential therapeutic benefits.
Used in Agrochemicals:
In the agrochemical industry, METHYL 6-CHLORO-1H-INDAZOLE-3-CARBOXYLATE is used as a precursor for the creation of active ingredients in pesticides and other crop protection products, leveraging its chemical properties to enhance crop yield and quality.
Used in Organic Synthesis:
METHYL 6-CHLORO-1H-INDAZOLE-3-CARBOXYLATE is utilized as a versatile building block in organic synthesis for the construction of a wide range of complex organic molecules, contributing to the advancement of chemical research and the development of novel compounds with diverse applications.

Upstream product

• 717134-46-8 (2-acetylamino-4-chloro-phenyl)-acetic acid methyl ester 
• 67-56-1 methanol 
• 503045-59-8 6-chloro-3-iodo-1H-indazole 
• 201230-82-2 carbon monoxide 
• 698-25-9 6-chloro-1H-indazole 
• 553-90-2 Dimethyl oxalate 
• 695-56-7 1,4-dioxaspiro[4.4]non-6-ene 

Relevant academic research and scientific papers

De Novo Synthesis of Benzannelated Heterocycles

Benzannelated heterocycles such as indoles and indazoles are prominent structural motifs found in natural products, pharmaceuticals and agrochemicals. For their synthesis, chemists traditionally either functionalize commercially available heterocycles or resort to transformations that make use of benzene-derived building blocks. Here, we report a powerful cascade reaction that enables the de novo construction of variously substituted indoles, indazoles, benzofurans and benzothiophenes from readily available bicyclo[3.1.0]hexan-2-ones. The transformation can be conducted under mild, non-anhydrous conditions. For the synthesis of indoles, mechanistic studies revealed that the electrocyclic ring-opening of the bicyclic ring-system and aromatization precedes the 3,3-sigmatropic rearrangement.

Synthesis of 3-indazolecarboxylic esters and amides via Pd-catalyzed carbonylation of 3-iodoindazoles

A straightforward and effective procedure for the preparation of 1H-indazole-3-carboxylic acid esters and amides was developed. A series of functionalized 3-iodoindazoles were subjected to Pd-catalyzed carbonylations in the presence of methanol or amines,

CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II

The invention discloses compounds of formula (I) wherein: R is a carboxylic acid or a derivative thereof; R1 and R2 are independently H or alkyl, or together R1 and R2 form an alkylene group; L1 is a

2-(1H-INDAZOL-6-YLAMINO)-BENZAMIDE COMPOUNDS AS PROTEIN KINASES INHIBITORS USEFUL FOR THE TREATMENT OF OPHTALMIC DISEASES

Indazole compounds that modulate and/or inhibit the ophthalmic diseases and the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating ophthalmic diseases and cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma,rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.