698-72-6

Usage

InChI:InChI=1/C5H5Cl2N3/c1-2-3-8-4(6)10-5(7)9-3/h2H2,1H3

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 925-90-6 ethylmagnesium bromide 
• 74-96-4 ethyl bromide 
• 2386-64-3 ethylmagnesium chloride 

Downstream Products

• 1258424-47-3 C₁₂H₁₀ClN₃O₂S 
• 1258205-33-2 C₁₅H₁₈N₈ 
• 1258205-34-3 C₁₅H₁₇N₇S 
• 1258423-31-2 C₁₉H₂₁N₇OS 
• 1258423-76-5 C₁₉H₂₀N₆OS₂ 
• 1258411-43-6 C₁₆H₁₄Cl₂N₆OS 
• 1258411-71-0 C₁₇H₁₇ClN₆OS 
• 1258411-26-5 C₂₁H₂₈N₈OS 
• 1258411-76-5 C₁₈H₁₉ClN₆OS 
• 1258411-27-6 C₂₂H₃₀N₈OS 
• 1035343-70-4 C₂₂H₂₇ClN₈O₂S 
• 1258411-22-1 C₂₁H₂₆ClN₉O₃ 
• 1258411-62-9 C₃₀H₃₆ClN₉O₂ 
• 1258411-23-2 C₂₂H₂₈ClN₉O 

Relevant academic research and scientific papers

ROCK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF

The invention relates to a ROCK inhibitor represented by formula (I), its preparation method and its use. The ROCK inhibitor has excellent ROCK inhibition activity, in particular good selective inhibition on ROCK2 kinase, has good safety and metabolic stability, and has high bioavailability. The process of preparing the ROCK inhibitor is simple, and the ROCK inhibitor is easy to purify, and therefore offers good prospects for application.

Glass engineering of aminotriazine-based materials with sub-ambient: T gand high kinetic stability

A challenge in glass engineering is the design of molecular glasses combining a high glass kinetic stability (GS) of the amorphous phase with a low (sub-ambient) glass transition temperature (Tg). Triazine derivatives with arylamino substituents readily form glassy phases that can show outstanding resistance to crystallization. In the present study, a series of 12 analogous compounds incorporating phenylamino and cyclohexylamino groups was synthesized, and their thermal properties and intermolecular interactions were studied. All compounds possess an excellent glass-forming ability, a low Tg ranging from 32 °C to as low as -19 °C, and a high GS. While the cyclohexyl derivatives show higher Tg, the phenyl derivatives possess a higher GS with some compounds remaining completely amorphous for over three years despite their sub-ambient Tg. X-ray diffraction, infrared spectroscopy and DFT calculations reveal that the higher volume occupancy and rotational energy barrier of cyclohexyl groups are the main factors responsible for the compounds' higher Tg values but that they also contribute to their higher propensity to crystallize. In counterpart, the planarity of phenyl groups leads to poorer packing and enhances their GS while keeping their Tg well below ambient. The formation of hydrogen bonds or competing interactions provides an additional handle to tune the Tg of the compounds. Taken together, these studies provide guidelines for the design of molecular glasses with readily tunable thermal properties in view of their functionalization. This journal is

Trizaine-based dehydrative condensation reagents bearing carbon-substituents

Herein, we report on the synthesis of alkyl-, aryl-, and alkynyl-substituted chlorotriazines and their ammonium salts, and demonstrate their utility in dehydrative condensation reactions. Although the electrophilicity of these reagents is mainly dependent on the hybridization of the carbon-substituents, it was found that bulky 2,6-dimethylphenyl group-substituted reagents resulted in the highest product yields because of a slight increase in reagent electrophilicity and/or steric hindrance favorable for desired dehydrative condensation reactions.

TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS

Compounds of the formula (I) and formula (II) and pharmaceutically acceptable salts thereof.

TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS

The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases.

TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS

The present invention comprises inter alia compounds as shown in formula (I) or a pharmaceutically acceptable salt thereof.

TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS

The present invention comprises inter alia triazine compounds as shown in formula (I) and pharmaceutically acceptable salts thereof.

UREIDOPHENYL SUBSTITUTED TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS

The present invention provides Uredophenyl substituted triazine derivatives and provides methods of using these compounds to modulate protein kinases and methods of using these compounds to treat protein kinase mediated diseases and conditions.

Anarchy in the solid state: structural dependence on glass-forming ability in triazine-based molecular glasses

We have recently shown that molecular glasses, small molecules capable of readily forming glassy solids as opposed to crystals, can be designed by exploiting molecular association through strong and directional intermolecular interactions, as exemplified by several members of the bis(mexylamino)triazine family. Herein, 43 new bis(mexylamino)triazine derivatives were synthesized, 31 of which have been found to spontaneously form glassy phases and did not crystallize upon heating. Crown Copyright

PREVENTIVES OR REMEDIES FOR ALZHEIMER'S DISEASE OR AMYLOID PROTEIN FIBROSIS INHIBITORS CONTAINING NITROGEN-CONTAINING HETEROARYL COMPOUNDS

The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereo