69803-60-7Relevant academic research and scientific papers
Synthesis and heterocyclization of β-aroyl-α- diphenylphosphorylpropionic acids
Khachatryan,Khachikyan,Karamyan,Panosyan,Indzhikyan
, p. 446 - 451 (2007/10/03)
It has been established that diphenylphosphine oxide reacts smoothly with β-aroylacrylic acids with the formation of β-aroyl-α- diphenylphosphorylpropionic acids, which were cyclized under the action of hydroxylamine, hydrazine hydrate, and phenylhydrazin
Diastereoselective nucleophilic additions to vinyl phosphine oxides
Barteis, Bjoern,Ciayden, Jonathan,Martin, Concepcion Gonzalez,Neison, Adam,Russell, Matthew G.,Warren, Stuart
, p. 1807 - 1822 (2007/10/03)
Some hydrogen, carbon, silicon, sulfur, nitrogen and oxygen nucleophiles react diastereoselectively with γ-oxygenated chiral vinyl phosphine oxides to give β-substituted phosphine oxides. Lithium N-benzyl-α-methylbenzylamide adds to prochiral vinyl phosphine oxides in the presence of trimethylsilyl chloride to provide, after protodesilylation, β-amino phosphine oxides as single diastereoisomers.
Asymmetric dihydroxylation of allylic phosphine oxides
Nelson, Adam,Warren, Stuart
, p. 2645 - 2657 (2007/10/03)
Diphenylphosphinoyl diols have been produced by asymmetric dihydroxylation (AD) of allylic phosphine oxides and have been shown to be useful synthetic intermediates. The results of this study are discussed in terms of the model which has been proposed by Sharpless to explain the enantioselectivity of his AD reaction. The dihydroxylation results are thus of both mechanistic and synthetic value.
Diastereoselective reactions of optically active γ-substituted vinyl phosphine oxides
Clayden, Jonathan,Nelson, Adam,Warren, Stuart
, p. 3471 - 3474 (2007/10/03)
Dehydration of diphenylphosphinoyl diols (synthesised by asymmetric dihydroxylation of allylic phosphine oxides) gives γ-hydroxy vinyl phosphine oxides. Some diastereoselective reactions of vinyl phosphine oxides with hydrogen, carbon and heteroatomic nucleophiles are discussed.
Synthesis of β-(Diphenylphosphinoyl) Ketones
Bell, Andrew,Davidson, Alan H.,Earnshaw, Chris,Norrish, Howard K.,Torr, Richard S.,et al.
, p. 2879 - 2892 (2007/10/02)
The title compounds may be made by addition of phosphorus nucleophiles (Ph2PO-, Ph2POMgX, Ph2PCl) to enones, by addition of phosphorus-stabilised carbanions to a α-carbonyl cation equivalents (2,3-dichloropropene, epoxides, and α-MeO-ketones) and by oxidation of allyl diphenylphosphine oxides.
