69813-84-9Relevant academic research and scientific papers
Highly efficient trialkylsilylcyanation of aldehydes, ketones and imines catalyzed by a nucleophilic N-heterocyclic carbene
Kano, Taichi,Sasaki, Kouji,Konishi, Teppei,Mii, Haruka,Maruoka, Keiji
, p. 4615 - 4618 (2007/10/03)
The synthetic utility of N-heterocyclic carbenes was demonstrated by the trialkylsilylcyanation of aldehydes, ketones and imines. In the presence of a catalytic amount of 3a, the reactions with Me3SiCN proceeded smoothly to give the corresponding cyanohydrin trimethylsilyl ethers or amino nitrile derivatives in good to excellent yields.
Activation of TMSCN by N-heterocyclic carbenes for facile cyanosilylation of carbonyl compounds
Song, Jinhua J.,Gallou, Fabrice,Reeves, Jonathan T.,Tan, Zhulin,Yee, Nathan K.,Senanayake, Chris H.
, p. 1273 - 1276 (2007/10/03)
N-Heterocyclic carbenes were found to be highly effective organocatalysts in activating TMSCN for facile cyanosilylation of carbonyl compounds. Cyano transfer from TMSCN to aldehydes and ketones proceeds at room temperature in the presence of only 0.01-0.
CYANIDE-ION-CATALYZED REACTION OF PENTAFLUOROPHENYLTRIMETHYLSYLANE WITH SUBSTITUTED ACETOPHENONES
Vyazankina, O. A.,Gostevskii, B. A.,Vyazankin, N. S.
, p. 145 - 150 (2007/10/02)
Treatment of pentafluorophenyltrimethylsilane (I) with enolizable ketones in the presence of catalytic amount of potassium cyanide-18-crown-6 complex gave the corresponding trimethylsilyl enol ethers.The same dehydrogenative silylation of highly crowded 2
