69818-95-7

Basic information

• Product Name: 2-methyl-N-(5-nitrothiazol-2-yl)benzamide
• Synonyms: 2-methyl-N-(5-nitrothiazol-2-yl)benzamide
• CAS NO: 69818-95-7
• Molecular Weight: 263.277
• Mol File: 69818-95-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-methyl-N-(5-nitrothiazol-2-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-N-(5-nitrothiazol-2-yl)benzamide(69818-95-7)
• EPA Substance Registry System: 2-methyl-N-(5-nitrothiazol-2-yl)benzamide(69818-95-7)

Safety Data

• Hazardous Substances Data: 69818-95-7(Hazardous Substances Data)

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 121-66-4 2-amino-5-nitro-1,3-thiazole 
• 933-88-0 ortho-toluoyl chloride 

Downstream Products

• 79798-95-1 2-[(2-methylbenzoyl)imino]-5-nitro-4-thiazoline-3-acetamide 

Relevant articles and documents

Structure-Activity Study of Nitazoxanide Derivatives as Novel STAT3 Pathway Inhibitors

We identified nitazoxanide (NTZ) as a moderate STAT3 pathway inhibitor through immunoblot analysis and a cell-based IL-6/JAK/STAT3 pathway activation assay. A series of thiazolide derivatives were designed and synthesized to further validate the thiazolide scaffold as STAT3 inhibitors. Eight out of 25 derivatives displayed potencies greater than that of NTZ, and their STAT3 pathway inhibitory activities were found to be significantly correlated with their antiproliferative activities in HeLa cells. Derivatives 15 and 24 were observed to be more potent than the positive control WP1066, which is under phase I clinical trials. Compared with NTZ, 15 also exhibited much improved in vivo pharmacokinetic parameters in rats and efficacies against proliferations in multiple cancer cell lines, indicating a broad-spectrum effect of these thiazolides as antitumor agents targeted on STAT3.

Heterocyclic chemicals, their preparation and use

Compounds of formula (III): STR1 wherein R5 is a single substituent in position 2 or 3 of the phenyl ring and when in the 2-position R5 is a chlorine atom, a methyl group or a nitro group; and R6 is a hydrogen atom or a CO

On the acylamino-2-nitro-5-pyridines and acylamino-2-nitro-5-thiazoles and their trichomonostatic activity.

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