69820-99-1Relevant academic research and scientific papers
Optically Active Quaternary Carbon Centers from the Photoaddition of Chromium-Alkoxycarbene Complexes and Optically Active Thiazolines
Thompson, Douglas K.,Suzuki, Naoki,Hegedus, Louis S.,Satoh, Yoshitaka
, p. 1461 - 1467 (2007/10/02)
The photolytic reaction of chromium-alkoxycarbene complexes with valine-derived, optically active thiazolines produced optically active β-lactam penam derivatives in fair to good yield and with high diastereoselectivity.In most cases alcoholysis of the β-lactam followed by solvolysis of the thiazolidine ring produced optically active quaternary centers having carbon substituents in four different oxidation states - alkane, alkoxy, aldehyde, and ester.The absolute configuration of the stereogenic center could be inverted by a sequence of redox manipulations of the ester and aldehyde group, making either enantiomer available from the same precursor.
Synthesis of (S)-(+)-6-hydroxy-2,5,7,8-tetramethylchroman-2-methanol and intermediates therein
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, (2008/06/13)
A process if disclosed for producing (S)-(+)-6-hydroxy-2,4,7,8-tetramethylchroman-2-methanol from either alkyl(R)-2-benzyloxy-3-hydroxy-2-methyl-propionate or (S)-2,2,4-trimethyl-1,3-dioxolan-4-ethanol including intermediates in this synthesis.
