698378-81-3

Usage

Uses

Used in Pharmaceutical Research:
Ethyl 2,2-difluoro-2-(3-fluorophenyl)acetate is used as a building block in the production of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable component in the synthesis of new drugs and therapeutic agents.
Used in Agrochemicals:
Ethyl 2,2-difluoro-2-(3-fluorophenyl)acetate is also utilized as a key intermediate in the manufacture of certain pesticides and herbicides. Its ability to be incorporated into complex molecules makes it a useful tool in the development of effective agricultural chemicals.
Used in Organic Synthesis:
Ethyl 2,2-difluoro-2-(3-fluorophenyl)acetate is used as a versatile reagent in organic synthesis. Its functional group compatibility allows it to be employed in a wide range of chemical reactions, contributing to the creation of diverse organic compounds.
Due to its unique structure and reactivity, Ethyl 2,2-difluoro-2-(3-fluorophenyl)acetate is the subject of ongoing research and development in the fields of medicinal chemistry and organic synthesis, with potential applications in various industries.

Upstream product

• 462-06-6 fluorobenzene 
• 698378-63-1 ethyl α,α-difluoro-α-(phenylseleno)acetate 
• 667-27-6 Ethyl bromodifluoroacetate 
• 1121-86-4 1-Fluoro-3-iodobenzene 

Relevant academic research and scientific papers

Synthetic method of aromatic ring group or aromatic heterocyclic tetrazole

The synthetic method comprises the following steps: (1) reacting 1.0 eq of ArI or HArI with 1.2 eq of ethyl 2, 2-difluoroacetate in the presence of DMSO as a solvent and 4.0 eq of Cu under the protection of nitrogen at 30 DEG C and 50 DEG C, and purifying to obtain a first intermediate compound; (2) dissolving 1.0 eq of the first intermediate compound in a mixed solvent of THF and water, adding 2.0 eq of LiOH, reacting at room temperature for 2 hours, spin-drying the solvent, adding HCl until the pH value is equal to 3, and filtering to obtain a second intermediate compound; and (3) reacting 1.0 eq of the second intermediate compound with 2.0 eq of diphenyl azide phosphate in the presence of 2.5 eq of triethylamine by taking tert-butyl alcohol as a solvent to generate aromatic ring group or aromatic heterocyclic tetrazole. The invention provides a novel synthetic method of aromatic ring group or aromatic heterocyclic tetrazole, wherein a target compound can be more conveniently obtained, and reagents participating in the reaction are low in toxicity, mild in reaction condition, simple and safe in aftertreatment, good in product quality and suitable for large-scale production.

COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES

Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.

Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif

2-Cyano-6-fluorophenylacetamide was explored as a novel P2 scaffold in the design of thrombin inhibitors. Optimization around this structural motif culminated in 14, which is a potent thrombin inhibitor (Ki = 1.2 nM) that exhibits robust effica

Aromatic substitution with photochemically generated difluoromethyl radicals bearing electron-withdrawing group

Novel and facile aromatic and heteroaromatic substitutions with difluoromethyl radicals bearing electron-withdrawing group generated by the photo-initiated Se-CF2 bond cleavage of ethyl α,α- difluoro-α-(phenylseleno)acetate and diethyl α,α- difluoromethyl-α-(phenylseleno)phosphonate were successfully carried out to provide the corresponding α-aryl-α,α-difluoroacetates and a-aryl-α,α-difluoromethylphosphonates in good to moderate yields.