69849-77-0Relevant academic research and scientific papers
A new 4-substituted-2-cyclohexenone synthesis
Booker-Milburn, Kevin I.,Thompson, David F.
, p. 7291 - 7294 (1993)
Conjugate addition of a variety of Grignard reagents to 2-cyclopentenone followed by cyclopropanation of the resulting enol ethers gave a range of substituted cyclopropyl silyl ethers in good yield. Treatment of these cyclopropyl silyl ethers with ferric chloride in DMF gave the one carbon ring expanded β-chloro ketones which were eliminated to the corresponding 4-substituted-2-cyclohexenones.
Trimethylsilyl Chloride/Tetramethylethylenediamine Facilitated Additions of Organocopper Reagents (RCu) to Enones
Johnson, Carl R.,Marren, Thomas J.
, p. 27 - 30 (2007/10/02)
Alkylcoppers (RCu) add readily in a conjugate fashion to enones in the presence of TMSCl and TMEDA to give high yields of trimethylsilyl enol ethers.
