69861-02-5

Basic information

• Product Name: N-(3-METHACRYLOXY-2-HYDROXYPROPYL)-3-AMINOPROPYLTRIETHOXYSILANE: 50% IN ETHANOL
• Synonyms: N-(3-METHACRYLOXY-2-HYDROXYPROPYL)-3-AMINOPROPYLTRIETHOXYSILANE: 50% IN ETHANOL;N-(3-METHACRYLOXY-2-HYDROXYPROPYL)-3-AMINOPROPYLTRIETHOXYSILANE, 50% in methanol;(3-methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane,tech-95;2-Propenoic acid, 2-Methyl-, 2-hydroxy-3-[3-[1,3,3,3-tetraMethyl-1-[(triMethylsilyl)oxy]disiloxanyl]prop oxy]propyl ester;3-(3-METHACRYLOXY-2-HYDROXYPROPOXY)PROPYLBIS(TRIMETHYLSILOXY)METHYLSILANE, tech-95;3-(3-METHACRYLOXY-2-HYDROXYPROPOXY)PROPYLBIS(TRIMETHYLSILOXY)METHYLSILANE
• CAS NO: 69861-02-5
• Molecular Formula: C₁₇H₃₈O₆Si₃
• Molecular Weight: 422.74
• Mol File: 69861-02-5.mol

Chemical Properties

• Boiling Point: 428.431°C at 760 mmHg
• Flash Point: 212.908°C
• Appearance: /
• Density: 0.910
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.4084
• Storage Temp.: below 5° C
• PKA: 13.07±0.20(Predicted)
• CAS DataBase Reference: N-(3-METHACRYLOXY-2-HYDROXYPROPYL)-3-AMINOPROPYLTRIETHOXYSILANE: 50% IN ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-METHACRYLOXY-2-HYDROXYPROPYL)-3-AMINOPROPYLTRIETHOXYSILANE: 50% IN ETHANOL(69861-02-5)
• EPA Substance Registry System: N-(3-METHACRYLOXY-2-HYDROXYPROPYL)-3-AMINOPROPYLTRIETHOXYSILANE: 50% IN ETHANOL(69861-02-5)

Safety Data

• TSCA: No
• Hazardous Substances Data: 69861-02-5(Hazardous Substances Data)

Usage

Uses

Used in Ophthalmic Applications:
N-(3-METHACRYLOXY-2-HYDROXYPROPYL)-3-AMINOPROPYLTRIETHOXYSILANE: 50% IN ETHANOL is used as a key component in the formulation of research silicone hydrogel contact lenses and other research ophthalmic devices. Its high oxygen permeability is the primary reason for its use in this application, as it helps to maintain the health and comfort of the eyes by allowing sufficient oxygen to reach the cornea.
Used in Research and Development:
This silicone monomer is also utilized in the research and development of novel ophthalmic materials and devices. Its unique properties and reactivity make it a valuable tool for scientists and researchers working on the design and synthesis of advanced materials for vision correction and eye care.

InChI:InChI=1/C16H33NO6Si/c1-6-21-24(22-7-2,23-8-3)11-9-10-17-12-15(18)13-20-16(19)14(4)5/h15,17-18H,4,6-13H2,1-3,5H3

Upstream product

• 79-41-4 poly(methacrylic acid) 
• 7422-52-8 1-bis(trimethylsilyloxy)methylsilyl-3-(oxiran-2-ylmethoxy)-1-propanol 
• 13234-23-6 lithium methacrylate 
• 6900-35-2 potassium methacrylate 
• 5536-61-8 sodium methacrylate 
• 1873-88-7 1,1,1,3,5,5,5-heptamethyltrisiloxan 
• 106-92-3 Allyl glycidyl ether 

Relevant articles and documents

Preparation method of organosilicon monomer compound

The invention relates to a preparation method of an organosilicon monomer compound. According to the preparation method, allyl glycidyl ether is used as a raw material and subjected to epoxy ring-opening substitution, hydrosilylation and a substitution esterification reaction to obtain the target compound. The method comprises the following steps: (1) subjecting an initial raw material to reacting with an alkali metal halide under the condition of a phase transfer catalyst to obtain an intermediate beta-halohydrin; (2) carrying out addition on the intermediate beta-halohydrin and bis(trimethylsiloxy)methylsilane under the catalysis of chloroplatinic acid to obtain an intermediate II; and (3) substituting the intermediate II with methacrylate to obtain a final compound. According to the above reaction synthesis route, generation of a large number of isomers in an existing method can be avoided, production of impurities is avoided in the aspect of reaction route design, and then, high-purity monomer is obtained.

METHOD FOR PRODUCING SILICONE MONOMER

To provide a method for purifying a polymerizable group-containing silicone monomer which can obtain a high-purity silicone monomer without causing gellation and increasing viscosity in concentrating and distilling a polymerizable group-containing silicone monomer.SOLUTION: There is provided a method for purifying a silicone monomer which comprises (A) a step of concentrating a solution containing a silicone monomer represented by the following formulas (1-a) or (1-b) (R1 is H or a methyl group; and A is a monovalent organo(poly)siloxanyl group-containing organic group), and (B) a step of subjecting the concentrated liquid obtained in (A) to reduced-pressure distillation, wherein a specific polymerization inhibitor is added before any one of the steps (A) and (B).SELECTED DRAWING: None

SILICONE COMPOUND PRODUCTION METHOD

PROBLEM TO BE SOLVED: To provide a polymerizable group-containing silicone monomer production method for realizing a high-purity silicone monomer by inhibiting generation of silylation products of impurities in a reaction stage of synthesis. SOLUTION: The production method comprises reacting an epoxy-containing organopolysiloxane represented by the general formula (1) in the figure (n is an integer from 1 to 10, and A is a siloxanyl group) with an acrylic or methacrylic acid in the presence of a transition metal Lewis acid. SELECTED DRAWING: None COPYRIGHT: (C)2022,JPOandINPIT

METHOD FOR PRODUCING SILOXANE

PROBLEM TO BE SOLVED: To provide a method for producing a siloxane compound suitable for a medical material. SOLUTION: There is produced a siloxane of the following formula (1) by reacting an epoxy compound represented by the following formula (5) and a (meth)acrylic acid. A is a group represented by the following formula (2) or the like. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

METHODS FOR PURIFYING SILOXANYL MONOMERS

Disclosed are reduced pressure distillation methods for purifying siloxanyl monomers in the presence of at least one polymerization inhibitor. In further aspects, the polymerization inhibitor can be an alkylhydroguinone or a hydroxynaphthalene. Also disclosed are compounds purified by the disclosed methods and polymers produced therefrom.

HYDROLYSIS-RESISTANT SILICONE COMPOUNDS

In one aspect, the invention relates to hydrolysis-resistant silicone compounds. In particular, disclosed are sterically hindered hydrolysis-resistant silicone compounds and improved purity hydrolysis-resistant silicone compounds. Also disclosed are processes for making hydrolysis-resistant silicone compounds; the products of the disclosed processes; compositions and polymers comprising the disclosed compounds and products of the disclosed processes; and ophthalmic lenses, for example contact lenses, intraocular lenses, artificial cornea, and spectacle lenses, comprising the disclosed compositions, disclosed polymers, disclosed compounds, and products of the disclosed processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

SILICONE COMPOUND AND PROCESS FOR PRODUCING THE SAME

This invention provides a process for producing of a silicone compound which includes a synthesis reaction of a silicone compound represented by the following formulas (a) and/or (a'), by reacting a carboxylic acid represented by the following formula (a2) to an epoxy silane represented by the following formula (a1) in presence of a metal salt of the carboxylic acid represented by the general formula (a2), characterized in that the reaction is carried out in presence of 0.05 wt% or more water in said reaction system. (Here, A denotes siloxanyl group. R1 denotes a substituent with 1 to 20 carbons having a polymerizable group. R2 to R4 respectively and independently denote hydrogen, a substituted or unsubstituted substituent with 1 to 20 carbons, or -X-A. X denotes a substituted or unsubstituted divalent substituent with 1 to 20 carbons.)

Process for the production of (trimethylsilyloxy)silylalkylglycerol methacrylates

The present invention relates to a process comprising the steps of reacting in the presence of a hydrosilylation catalyst, a first reaction mixture comprising a free radical reactive compound and a silicon containing compound to form a silicon substituted glyceryl (meth)acrylate.

PROCESS FOR THE PRODUCTION OF BIS(TRIMETHYLSILOXY)SILYLALKYLGLYCEROL METHACRYLATES

The present invention relates to a process comprising the steps of reacting a substituted epoxide, and preferably a silicone containing substituted epoxide with at least one lithium acrylic acid salt, at least one acrylic acid and optionally at least one inhibitor at a temperature above about 60°C to form a substituted hydroxy acrylate.

PROCESS FOR THE PRODUCTION OF BIS(TRIMETHYLSILYLOXY)SILYLALKYLGLYCEROL METHACRYLATES

The present invention relates to a process for producing substituted glycerol acrylates from substituted epoxides. More specifically, the present invention relates to a process comprising the steps of (a) reacting a first reaction mixture comprising substituted epoxide with at least one epoxide opening catalyst and at least one acrylic acid to form a first reaction product comprising between about 60 and about 85 mole % substituted glycerol acrylate and said substituted epoxide; (b) treating said first reaction mixture with a nucleophilic compound to form a second reaction product which is substantially free of said substituted epoxide and which comprises said substituted glycerol acrylate and a nucleophile derivative of said substituted epoxide; and (c) treating said second reaction product to remove said nucleophile derivative and produce substituted glycerol acrylate having less than about 5 weight % difunctional impurities.