69891-57-2

Upstream product

• 69891-92-5 2-(1,3-dioxan-2-yl)ethyltriphenylphosphonium bromide 

Downstream Products

• 77332-94-6 (-)-(4S-trans)(Z)-2,2-dimethyl-5-<3-(1,3-dioxan-2-yl)-1-propenyl>-1,3-dioxolane-4-methanol benzoate 
• 85628-98-4 (+)-(4S-cis)-2,2-dimethyl-5-<<<(4-methylphenyl)sulfonyl>oxy>methyl>-1,3-dioxolane-4-butanoic acid 3-hydroxypropyl ester 
• 77332-94-6 (+)-(4R-cis)(Z)-2,2-dimethyl-5-<3-(1,3-dioxan-2-yl)-1-propenyl>-1,3-dioxolane-4-methanol benzoate 
• 77333-00-7 (-)-(4S-trans)-2,2-dimethyl-5-<3-(1,3-dioxan-2-yl)propyl>-1,3-dioxolane-4-methanol benzoate 
• 77333-00-7 (+)-(4R-cis)-2,2-dimethyl-5-<3-(1,3-dioxan-2-yl)-1-propyl>-1,3-dioxolane-4-methanol benzoate 
• 77333-01-8 (-)-(4S-trans)-5-<(benzoyloxy)methyl>-2,2-dimethyl-1,3-dioxolane-4-butanoic acid 3-hydroxypropyl ester 
• 77333-01-8 (+)-(4S-cis)-2,2-dimethyl-5-<(benzoyloxy)methyl>-1,3-dioxolane-4-butanoic acid 3-hydroxypropyl ester 

Relevant academic research and scientific papers

Synthesis of unsaturated organotrifluoroborates via Wittig and Horner-Wadsworth-Emmons olefination

The stereoselective synthesis of unsaturated organotrifluoroborates by using the Wittig and Horner-Wadsworth-Emmons olefination is described. These reactions were general for both alkyl- and aryltrifluoroborates. The synthesis of di- and trisubstituted ol

AMIDINOHYDRAZONES AS PROTEASE INHIBITORS

Amidino and benzamidino compounds, including compounds of the formula: I wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I.

Enantiospecific syntheses of leukotrienes C4, D4 and E4 and [14,15-3H2]leukotriene E4 dimethyl ester

A 'chiral-pool' approach was employed to synthesize various leukotrienes (slow-reacting substance of anaphylaxis, SRS-A) enantiospecifically. The pivotal (S,S)-trans-epoxy alcohol 9 was prepared by efficient and facile routes starting from erythorbic acid (D-araboascorbic acid, 13). This epoxide could also be produced starting from D-glucose. The epimeric (S,R)-cis-epoxide 38 was obtained utilizing L-tartaric acid as the chiral starting material. Elaboration of 9 into leukotriene A4 methyl ester (5) and the potassium salts of leukotrienes C4 (4a), D4 (4b), and E4 (4c) was accomplished by standard methods. These salts exhibited potent contractile activities in the in vitro guinea pig ileum assay. Reduction of 14,15-dehydroleukotriene A4 methyl ester (44) with tritium gas gave [14,15-3H2]-5 and subsequently the dimethyl ester of [14,15-3H2]leukotriene E4 having a high specific activity of 40 Ci/mmol.