77333-01-8

Basic information

• Product Name: (+)-(4S-cis)-2,2-dimethyl-5-<(benzoyloxy)methyl>-1,3-dioxolane-4-butanoic acid 3-hydroxypropyl ester
• Synonyms: (+)-(4S-cis)-2,2-dimethyl-5-<(benzoyloxy)methyl>-1,3-dioxolane-4-butanoic acid 3-hydroxypropyl ester
• CAS NO: 77333-01-8
• Molecular Weight: 380.438
• Mol File: 77333-01-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+)-(4S-cis)-2,2-dimethyl-5-<(benzoyloxy)methyl>-1,3-dioxolane-4-butanoic acid 3-hydroxypropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(4S-cis)-2,2-dimethyl-5-<(benzoyloxy)methyl>-1,3-dioxolane-4-butanoic acid 3-hydroxypropyl ester(77333-01-8)
• EPA Substance Registry System: (+)-(4S-cis)-2,2-dimethyl-5-<(benzoyloxy)methyl>-1,3-dioxolane-4-butanoic acid 3-hydroxypropyl ester(77333-01-8)

Safety Data

• Hazardous Substances Data: 77333-01-8(Hazardous Substances Data)

Upstream product

• 25581-41-3 D-erythronolactone acetonide 
• 53691-70-6 4,6-O-isopropylidene-D-glucopyranose 
• 69891-57-2 dioxanylethyl phosphorane 
• 69891-92-5 2-(1,3-dioxan-2-yl)ethyltriphenylphosphonium bromide 
• 85612-85-7 [(4R,5S)-5-((Z)-3-[1,3]Dioxan-2-yl-propenyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-methanol 
• 77332-94-6 (+)-(4R-cis)(Z)-2,2-dimethyl-5-<3-(1,3-dioxan-2-yl)-1-propenyl>-1,3-dioxolane-4-methanol benzoate 
• 189996-60-9 2,3-O-isopropylidene-D-erythrose 
• 77333-00-7 (-)-(4S-trans)-2,2-dimethyl-5-<3-(1,3-dioxan-2-yl)propyl>-1,3-dioxolane-4-methanol benzoate 
• 77398-79-9 (-)-(S,S)-2,2-dimethyl-1,3-dioxolane-4,5-dimethanol monobenzoate 
• 77332-99-1 (+)-(4R-trans)-5-<(benzoyloxy)methyl>-2,2-dimethyl-1,3-dioxolane-4-carboxaldehyde 
• 98-88-4 benzoyl chloride 
• 77332-94-6 (-)-(4S-trans)(Z)-2,2-dimethyl-5-<3-(1,3-dioxan-2-yl)-1-propenyl>-1,3-dioxolane-4-methanol benzoate 

Downstream Products

• 77333-02-9 (+)--6-<2-<(benzoyloxy)-1-hydroxy>ethyl>tetrahydro-2H-pyran-2-one 
• 73466-12-3 Leukotriene A₄ methyl ester 
• 73957-99-0 (-)-(S,S-trans)-3-(hydroxymethyl)oxiranebutanoic acid methyl ester 
• 73958-00-6 (5S,6S)-epoxy-10-formyl-(7E,9E)-decadienoic acid methyl ester 
• 77332-98-0 Benzoic acid (R)-2-methanesulfonyloxy-2-((S)-6-oxo-tetrahydro-pyran-2-yl)-ethyl ester 
• 77350-18-6 Benzoic acid (S)-2-methanesulfonyloxy-2-((S)-6-oxo-tetrahydro-pyran-2-yl)-ethyl ester 

Relevant articles and documents

Enantiospecific syntheses of leukotrienes C4, D4 and E4 and [14,15-3H2]leukotriene E4 dimethyl ester

A 'chiral-pool' approach was employed to synthesize various leukotrienes (slow-reacting substance of anaphylaxis, SRS-A) enantiospecifically. The pivotal (S,S)-trans-epoxy alcohol 9 was prepared by efficient and facile routes starting from erythorbic acid (D-araboascorbic acid, 13). This epoxide could also be produced starting from D-glucose. The epimeric (S,R)-cis-epoxide 38 was obtained utilizing L-tartaric acid as the chiral starting material. Elaboration of 9 into leukotriene A4 methyl ester (5) and the potassium salts of leukotrienes C4 (4a), D4 (4b), and E4 (4c) was accomplished by standard methods. These salts exhibited potent contractile activities in the in vitro guinea pig ileum assay. Reduction of 14,15-dehydroleukotriene A4 methyl ester (44) with tritium gas gave [14,15-3H2]-5 and subsequently the dimethyl ester of [14,15-3H2]leukotriene E4 having a high specific activity of 40 Ci/mmol.