69895-75-6Relevant academic research and scientific papers
Reactions of Substituted Indoles with 2,3-Dichloro-1,4-naphthoquinone and Electrochemical Properties of Some 2,3-Substituted 1,4-Naphthoquinones
Ibis,Ayla, S. Sahinler,Tulegenova,Bahar
, p. 546 - 553 (2019)
The reactions of 2,3-dichloro-1,4-naphthoquinone with some indoles and thiols were investigated. The resulting nucleophilic substitution products were characterized by spectroscopic methods (FT-IR, 1H and 13C NMR, MS) and microanalys
Composition for Distructing Microalgae
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Paragraph 0414-0417, (2017/09/05)
The present invention relates to a composition for destroying microalgae, more specifically, to a composition for destroying microalgae containing naphthoquinone compounds having a specific exchange group. The composition for destroying microalgae, according to the present invention, can prevent green tide and red tide by being processed in areas such as cultivation facilities for microalgae, areas in which the green tide or the red tide occur, or areas expected to occur the green tide or the red tide.
Dioxonaphthoimidazoliums are Potent and Selective Rogue Stem Cell Clearing Agents with SOX2-Suppressing Properties
Ho, Si-Han Sherman,Ali, Azhar,Ng, Yi-Cheng,Lam, Kuen-Kuen Millie,Wang, Shu,Chan, Woon-Khiong,Chin, Tan-Min,Go, Mei-Lin
supporting information, p. 1944 - 1955 (2016/10/06)
Pluripotent stem cells are uniquely positioned for regenerative medicine, but their clinical potential can only be realized if their tumorigenic tendencies are decoupled from their pluripotent properties. Deploying small molecules to remove remnant undifferentiated pluripotent cells, which would otherwise transform into teratomas and teratomacarcinomas, offers several advantages over non-pharmacological methods. Dioxonapthoimidazolium YM155, a survivin suppressant, induced selective and potent cell death of undifferentiated stem cells. Herein, the structural requirements for stemotoxicity were investigated and found to be closely aligned with those essential for cytotoxicity in malignant cells. There was a critical reliance on the quinone and imidazolium moieties but a lesser dependence on ring substituents, which served mainly to fine-tune activity. Several potent analogues were identified which, like YM155, suppressed survivin and decreased SOX2 in stem cells. The decrease in SOX2 would cause an imbalance in pluripotent factors that could potentially prompt cells to differentiate and hence decrease the risk of aberrant teratoma formation. As phosphorylation of the NF-κB p50 subunit was also suppressed, the crosstalk between phospho-p50, SOX2, and survivin could implicate a causal role for NF-κB signaling in mediating the stem cell clearing properties of dioxonaphthoimidazoliums.
