699-03-6

Basic information

• Product Name: (4-BROMOBENZYL)METHYLAMINE
• Synonyms: 4-BROMO-N-METHYLBENZYLAMINE;(4-BROMOBENZYL)METHYLAMINE;(4-Bromobenzyl)methylamine95%;N-Methyl-4-bromobenzylamine;874-73-7 (Hydrochloride);Aids107181;Aids-107181;Benzenemethanamine, 4-bromo-N-methyl-
• CAS NO: 699-03-6
• Molecular Formula: C₈H₁₀BrN
• Molecular Weight: 200.08
• Product Categories: Amines and Anilines;amine| alkyl bromide
• Mol File: 699-03-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 218-219 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.00 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0478mmHg at 25°C
• Refractive Index: n20/D 1.5650(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.52±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: (4-BROMOBENZYL)METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMOBENZYL)METHYLAMINE(699-03-6)
• EPA Substance Registry System: (4-BROMOBENZYL)METHYLAMINE(699-03-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36
• WGK Germany: 2
• Hazardous Substances Data: 699-03-6(Hazardous Substances Data)

Usage

General Description

(4-Bromobenzyl)methylamine is a chemical compound with the molecular formula C8H10BrN. It is a derivative of benzylamine, with a bromine atom attached to the benzene ring. (4-BROMOBENZYL)METHYLAMINE is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. It is also a valuable intermediate for the synthesis of different types of organic compounds due to its versatile reactivity. Additionally, (4-Bromobenzyl)methylamine can be used as a ligand in coordination chemistry and as a substrate in the study of enzyme-catalyzed reactions. Overall, this chemical has a wide range of applications in the fields of chemistry, pharmaceuticals, and biochemistry.

InChI:InChI=1/C8H10BrN/c1-10-6-7-2-4-8(9)5-3-7/h2-5,10H,6H2,1H3/p+1

Upstream product

• 589-17-3 p-bromobenzyl chloride 
• 74-89-5 methylamine 
• 1122-91-4 4-bromo-benzaldehyde 
• 86402-04-2 N-(p-bromobenzylidene)methylamine 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 6274-57-3 (4-bromobenzyl)dimethylamine 
• 35003-56-6 1-(4-bromophenyl)-N-methylmethanimine 

Downstream Products

• 160528-76-7 4-hydroxy-4-(4-methylaminomethyl-phenyl)-cyclohexanone-ethylene-ketal 
• 1092060-53-1 C₂₅H₂₄BrFN₂ 
• 1092060-65-5 C₂₆H₂₆BrFN₂ 
• 1174903-48-0 3-[[(4-bromobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 41690-89-5 (4-butoxy-benzyl)-methyl-amine 
• 103-67-3 benzyl-methyl-amine 
• 1247891-93-5 N-(4-bromobenzyl)-N-methylbut-3-enamide 
• 23966-25-8 methyl 6-(2-methyl-1-oxoisoindoline)carboxylate 
• 1520080-43-6 methyl 4-((N-methylbut-3-enamido)methyl)benzoate 
• 1254319-51-1 N-methyl-6-bromoisoindoline-1-one 
• 1520080-47-0 (E)-N-(4-bromobenzyl)-N-methylhept-3-enamide 
• 1520080-32-3 (9H-fluoren-9-yl)methyl 4-bromobenzyl(methyl)carbamate 
• 1304633-64-4 phenyl 4-bromobenzyl(methyl)carbamate 
• 1520080-31-2 n-propyl 4-bromobenzyl(methyl)carbamate 

Relevant articles and documents

Copper-Mediated Radiosynthesis of [18F]Rucaparib

The poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib is used in the clinic to treat BRCA-mutated cancers. Herein, we report two strategies to access the 18F-isotopologue of rucaparib by applying a copper-mediated nucleophilic 18F-fluorodeboronation. The most successful approach features an aldehydic boronic ester precursor that is subjected to reductive amination post-18F-labeling and affords [18F]rucaparib with an activity yield of 11% ± 3% (n = 3) and a molar activity (Am) up to 30 GBq/μmol. Preliminary in vitro studies are presented.

SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

Smooth isoindolinone formation from isopropyl carbamates via bischler-napieralski-type cyclization

Isopropyl carbamates derived from benzylamines provide isoindolinones by treatment with phosphorus pentoxide at room temperature. Utility of this Bischler-Napieralski-type cyclization and a new mechanism involving a carbamoyl cation for rationalization of this smooth conversion are discussed.