699009-77-3Relevant academic research and scientific papers
Enantioselective synthesis of pseudotripeptides incorporating a γ-methylene derivative of 2,6-diaminopimelic acid: Part 6
Balducci, Daniele,Porzi, Gianni,Sandri, Sergio
, p. 1085 - 1093 (2007/10/03)
An efficient enantioselective synthesis of pseudotripeptides 5, 8a-d and 13a and b incorporating a 2,6-diamino-4-methylene-1,7-heptandioic acid residue, has been accomplished starting from the glycine derived chiral synthon 1 (from L-valine). The absolute configuration of the new stereocentres was assigned on the basis of 1H NMR spectra. The geometry of derivative 4 was deduced on the basis of 1H NMR parameters (δNH value, temperature coefficient, δNH change upon addition of DMSO or CD3OD, NOE studies) and IR spectra.
