69905-99-3Relevant academic research and scientific papers
Visible-light-mediated reaction: Synthesis of quinazolinones from 1,2-dihydroquinazoline 3-oxides
Wu, Chun-Ku,Yang, Ding-Yah
, p. 65988 - 65994 (2016/07/26)
1-Methyl-2-phenylquinazolin-4(1H)-ones were synthesized in good yield by exposing 1,4-dimethyl-2-phenyl-1,2-dihydroquinazoline 3-oxides or 1-methyl-2-phenyl-1,2-dihydroquinazoline 3-oxides to visible light in acetonitrile in the absence of any external ph
Bridgehead nitrogen heterocycles which contain the quinazoline moiety - Synthesis and cycloaddition of 1,2-dihydroquinazoline 3-oxides
Heaney, Frances,McCarthy, Tomas,Mahon, Mary,McKee
, p. 4351 - 4361 (2007/10/03)
A novel synthesis of 1,2-disubstituted 1,2-dihydroquinazoline 3-oxides 8 and the first ever examples of 1,3-dipolar trapping of these nitrones to homonuclear dipolarophiles is described. The new dipoles 8 reacted with N-methyl maleimide, generating diastereomeric adducts 14-16. In the reaction between 8 and dimethyl acetylenedicarboxylate, primary cycloadducts 17 and/or stable rearrangement products, azomethine ylides 18, are formed depending on the substitution pattern of the dipole. The structure of 18c is unambiguously assigned by X-ray crystallographic analysis. An X-ray crystal structure determination is also presented for the cyclopropylisoxazoloquinazoline 22 formed by a [3 + 2] addition of 8a to 21, the dimethyl acetylenedicarboxylate tetramer. The Royal Society of Chemistry 2005.
