69918-17-8

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 
• 1456-22-0 3-phenyl-4H-[1,2,4]oxadiazol-5-one 
• 74763-71-6 1-(4-bromophenyl)-1-methylhydrazine 
• 100-47-0 benzonitrile 
• 613-92-3 N-hydroxyl-benzamidine 
• 937-23-5 4-bromo-N-nitroso-N-methylaniline 
• 825-60-5 benzimidic acid ethyl ester 
• 59488-34-5 (4-bromo-2-nitrophenyl)hydrazine 

Relevant academic research and scientific papers

Stability of a columnar liquid crystalline phase in isomeric derivatives of the 1,4-dihydrobenzo[e][1,2,4]triazin-4-yl: Conformational effects in the core

Fluid phase behaviour of three isomeric 1,3,6-trisubstituted benzo[e][1,2,4]triazin-4-yl derivatives with the half-disc molecular architecture was examined in the pure form and in binary mixtures. Results indicate that the position of substitution with two wedge-shaped 3,4,5-tridodecyloxyphenyl groups and one Ph group has dramatic impact on the Colh phase stability, which ranges from 73 °C to presumably below ?60 °C. Analysis of electronic and steric factors suggests that the intermolecular interactions of the wedge-shaped substituents are dominant and through their conformational behaviour they affect packing of the column's core and hence phase stability.

Cobalt-Catalyzed, Directed Intermolecular C-H Bond Functionalization for Multiheteroatom Heterocycle Synthesis: The Case of Benzotriazine

Transition-metal-catalyzed, directed intermolecular C-H bond functionalization is synthetically useful but heavily underexplored in multiheteroatom heterocycle synthesis. Herein we report a cobalt catalytic method for the formation of a three-nitrogen-bearing benzotriazine scaffold via the coupling of arylhydrazine and oxadiazolone. This synthetic protocol features a low-cost base metal catalyst, a maximum number of heteroatoms built into a heterocycle, a distinct synthetic logic for benzotriazines, a superior step economy, and a broad substrate scope.

Two-step syntheses of 3-methyl and 3-phenyl-1,2,4-benzotriazines

3-Methyl-1,2,4-benzotriazine and some of its derivatives were prepared in moderate yields (50-70%) via a reductive cyclization by a PtO 2-catalyzed hydrogenation of the corresponding 2- nitrophenylhydrazones of the pyruvic acid. The latter comp