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(2-hydroxy-4-methoxyphenyl)(4-nitrophenyl)methanone is a complex organic compound with the molecular formula C15H11NO5. It is a derivative of benzophenone, characterized by the presence of a hydroxyl group at the 2-position and a methoxy group at the 4-position of one phenyl ring, while the other phenyl ring is substituted with a nitro group at the 4-position. (2-hydroxy-4-methoxyphenyl)(4-nitrophenyl)methanone is known for its potential applications in the synthesis of various pharmaceuticals and agrochemicals due to its unique structure and reactivity. It is also used as an intermediate in the preparation of dyes and pigments. The compound is typically synthesized through a condensation reaction involving the corresponding phenolic and aromatic aldehyde or ketone derivatives.

6994-36-1

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6994-36-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6994-36-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,9 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6994-36:
(6*6)+(5*9)+(4*9)+(3*4)+(2*3)+(1*6)=141
141 % 10 = 1
So 6994-36-1 is a valid CAS Registry Number.

6994-36-1Relevant academic research and scientific papers

On the synthesis and biological properties of isocombretastatins: A case of ketone homologation during Wittig reaction attempts

Stocker, Vivien,Ghinet, Alina,Leman, Marie,Rigo, Benoit,Millet, Regis,Farce, Amaury,Desravines, Deborah,Dubois, Joelle,Waterlot, Christophe,Gautret, Philippe

, p. 3683 - 3696 (2013/04/11)

New isocombretastatins were synthesized by reacting the corresponding phenstatin analogs with CH3PPh3Br in presence of tBuOK. These new derivatives showed significant activities against cellular proliferation and tubulin polymerization. In particular, monomethoxylated derivatives of phenstatin and isoCA-4 exhibit similar activities to those of parent phenstatin. Attempts of the Wittig reaction on 2- (or 4-) methoxy-4′-nitrobenzophenones in the same conditions do not lead to the expected isocombretastatins but to methyleneketones with the exclusion of triphenylphosphine. A mechanism for this new ketone homologation was proposed.

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