6994-45-2Relevant articles and documents
Preparation method for ion pair chromatographic reagent sodium 1-tetradecanesulphonate
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Paragraph 0023-0027, (2017/01/09)
The invention relates to a preparation method for ion pair chromatographic reagent sodium 1-tetradecanesulphonate. The method comprises the following steps: adding anhydrous sodium sulfite, water, 1-myristyl bromide and tetrapropylammonium bromide in sequence in a reaction container provided with a cooling reflux device and a mechanical stirring device, sulfonating for 16-24 hours, then evaporating water in a mixture after the sulfonation reaction through pressure reduction, drying and crushing remaining solid, putting in a Soxhlet extractor, extracting with absolute ethyl alcohol to generate a crude product, then recrystallizing the crude product with absolute ethyl alcohol, filtering and purifying twice to obtain a pure product, and finally drying for 2-4 hours to obtain a finished product. According to the preparation method, in the sulfonation reaction process of the sodium sulfite and the 1-myristyl bromide, the tetrapropylammonium bromide is taken as a crystal, and the activity of the 1-myristyl bromide is strengthened, so that the sulfonation reaction can be carried out successfully, the generation of byproducts is reduced, and the reaction time is obviously shortened.
Sulfonyl urea and carbamate ACAT inhibitors
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, (2008/06/13)
A pharmaceutically useful compound which lowers blood cholesterol levels having the formula STR1 wherein X is oxygen or --NH--; Ar is phenyl, substituted phenyl, naphthyl or substituted naphthyl; R1 is hydrogen, lower alkyl or benzyl; and Rsub