6995-49-9Relevant academic research and scientific papers
Asymmetric syntheses and bio-evaluation of novel chiral esters derived from substituted tetrafluorobenzyl alcohol
Xu, Shengzhen,Li, Huangyong,Wang, Xiaohui,Chen, Changshui,Cao, Minhui,Cao, Xiufang
supporting information, p. 2734 - 2736 (2015/02/19)
A series of novel chiral esters derived from tetrafluorobenzyl alcohol were designed and prepared via asymmetric synthesis. The target molecules have been identified on the basis of analytical spectra data. All newly synthesized compounds have been screened their potential insecticidal activity against Plutella xylostella compared with those of fenvalerate and d-trans-phenothrin by standard method, and the respective pairs of enantiomers (3-B1-R/S, 3-C1-R/S, 3-D1-R/S) indicated significantly different activities.
Asymmetric syntheses and bio-evaluation of novel chiral esters derived from substituted tetrafluorobenzyl alcohol
Xu, Shengzhen,Li, Huangyong,Wang, Xiaohui,Chen, Changshui,Cao, Minhui,Cao, Xiufang
supporting information, p. 2734 - 2736 (2014/06/09)
A series of novel chiral esters derived from tetrafluorobenzyl alcohol were designed and prepared via asymmetric synthesis. The target molecules have been identified on the basis of analytical spectra data. All newly synthesized compounds have been screened their potential insecticidal activity against Plutella xylostella compared with those of fenvalerate and d-trans-phenothrin by standard method, and the respective pairs of enantiomers (3-B1-R/S, 3-C1-R/S, 3-D1-R/S) indicated significantly different activities.
Rh-catalyzed addition of β-carbonyl pinacol alkylboronates to aldehydes: Asymmetric synthesis of γ-butyrolactones
Zhang, Changwan,Yun, Jaesook
, p. 3416 - 3419 (2013/07/26)
The rhodium-catalyzed 1,2-addition of chiral benzylic secondary alkylboronic esters with a coordinating carbonyl group to aldehydes was demonstrated with high levels of enantiospecificity. Pinacol boronic ester derivatives can be employed directly for the addition in the presence of KHF2 without the use of corresponding trifluoroborate salts where retention of the configuration was observed. Enantiomerically enriched β,γ-diaryl-substituted γ-butyrolactones were synthesized in good yields.
Enantioenriched acid, ester, and ketone β-phenyl homoenolate synthetic equivalents from N-Boc-N-(p-methoxyphenyl)cinnamylamine
Whisler,Soli,Beak
, p. 9527 - 9531 (2007/10/03)
Oxidation of the β-substituted highly enantioenriched aldehydes obtained by hydrolysis of the 3,3-disubstituted enecarbamates affords enantioenriched β-substituted acids and esters. Lithiation of enantio-enriched 3,3-disubstituted enecarbamates and subsequent reaction with electrophiles provides vinylically substituted enecarbamates. The use of benzyl and alkyl halide electrophiles affords α-substituted enecarbamates, which can be hydrolyzed to provide enantioenriched β-substituted ketones. Reaction of the lithiated intermediate with ketones affords oxazolidinones, which can be reductively ring-opened with DIBAL and hydrolyzed to provide enantioenriched β-substituted, α'-hydroxy ketones. These transformations demonstrate that the enantioselective lithiation of N-Boc-N-(p-methoxyphenyl)cinnamylamine provides a reactive intermediate which can be a ketone, acid, or ester homoenolate synthon. (C) 2000 Published by Elsevier Science Ltd.
Asymmetric Michael additions of Grignard reagents to cinnamamides deriving from N-alkyl (R)-(-)-2-aminobutan-1-ol
Touet,Baudouin,Brown
, p. 587 - 590 (2007/10/02)
Reaction of cinnamoyl chloride with various N-alkyl derivatives of (R)-(-)-2-aminobutan-1-ol (a readily available reagent) afforded the corresponding cinnamamides. Michael additions of Grignard reagents to the latter, followed by acidic hydrolysis, yielde
