69951-04-8

Upstream product

• 608-27-5 2,3-dichloroaniline 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 69951-03-7 2,3-dichloro-4-nitroaniline 
• 947407-72-9 C₁₇H₁₇NSO₄Cl₂ 
• 947407-77-4 C₁₅H₁₅N₃SO₃Cl₂ 
• 884987-17-1 C₁₅H₁₃NSO₄Cl₂ 
• 69951-05-9 2-Chloro-3-methoxy-4-nitroaniline 
• 69950-98-7 C₁₇H₂₉ClN₄O₇P₂S₂ 
• 69950-97-6 C₁₉H₃₃ClN₄O₆P₂S₃ 
• 1599442-34-8 4-(4-methoxyphenyl)-2-phenyl-1-tosyl-1H-indole 
• 1599442-43-9 2-decyl-4-(4-methylphenyl)-1-tosyl-1H-indole 
• 1599442-44-0 2-decyl-4-(4-fluorophenyl)-1-tosyl-1H-indole 
• 1599442-45-1 2-decyl-4-(4-trifluoromethylphenyl)-1-tosyl-1H-indole 
• 1599442-48-4 2-decyl-4-(3-thienyl)-1-tosyl-1H-indole 
• 1599442-47-3 2-decyl-4-(3-methoxyphenyl)-1-tosyl-1H-indole 
• 1599442-49-5 2-decyl 4-(1-trans-1-octen-1-yl)-1-tosyl-1H-indole 

Relevant academic research and scientific papers

One-Pot Synthesis of Substituted Benzo[b]furans and Indoles from Dichlorophenols/Dichloroanilines Using a Palladium-Dihydroxyterphenylphosphine Catalyst

Disubstituted benzo[b]furans were synthesized by ortho-selective Sonogashira coupling of dichlorophenols and terminal alkynes, followed by cyclization and Suzuki-Miyaura coupling in one pot, using a palladium-dihydroxyterphenylphosphine (Cy-DHTP) catalyst. The use of substoichiometric amounts of tetrabutylammonium chloride was effective in accelerating the Suzuki-Miyaura coupling. This protocol was also successfully applied to the one-pot synthesis of disubstituted indoles from dichloroaniline derivatives.

One-pot synthesis of 2,4-disubstituted indoles from N-tosyl-2,3- dichloroaniline using palladium-dihydroxyterphenylphosphine catalyst

4-Chloroindoles were synthesized from readily available 2,3-dichloroaniline derivatives and terminal alkynes. The catalyst composed of palladium and dicyclohexyl(dihydroxyterphenyl)phosphine (Cy-DHTP) enabled ortho-selective Sonogashira coupling, and subsequent cyclization afforded 4-chloroindoles in high yields. This transformation was successfully applied to the one-pot synthesis of 2,4-disubstituted indoles via Suzuki-Miyaura coupling after indole formation.

Identification and optimization of novel 1,3,4-oxadiazole EP1 receptor antagonists

A novel series of oxadiazole EP1 receptor antagonists was identified by replacing the amide of a known glycine sulfonamide derivative with a 1,3,4-oxadiazole. Optimization of the substitution patterns on the three aromatic rings led to the iden