699536-25-9Relevant academic research and scientific papers
Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743
Torikai, Kohei,Saruwatari, Takayoshi,Kitano, Tatsuya,Sano, Takuya,Nakane, Atsuko,Noguchi, Hiroshi,Watanabe, Kenji
experimental part, p. 686 - 689 (2012/06/30)
A practical synthetic route of DOPA derivative 2, which should be useful for direct biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743 was established. The developed strategy features i) easy-to-handle reactions without special care upon both dryness and inert atmopsphere, and ii) the facile HPLC-free purification of 2 via recrystallization enabling scalable synthesis of 2.
Synthesis of tyrosine derivatives for saframycin MX1 biosynthetic studies
Schmidt, Eric W.,Nelson, James T.,Fillmore, John P.
, p. 3921 - 3924 (2007/10/03)
Saframycin MX1 and structural relatives are natural anticancer agents isolated from bacteria and marine invertebrates. For biosynthetic studies and to make a library of modified natural products, a series of tyrosine derivatives were synthesized in a conc
