69955-51-7Relevant academic research and scientific papers
Utilization of fluoroform for difluoromethylation in continuous flow: A concise synthesis of α-difluoromethyl-amino acids
K?ckinger, Manuel,Ciaglia, Tanja,Bersier, Michael,Hanselmann, Paul,Gutmann, Bernhard,Kappe, C. Oliver
, p. 108 - 112 (2018)
Fluoroform (CHF3) can be considered as an ideal reagent for difluoromethylation reactions. However, due to the low reactivity of fluoroform, only very few applications have been reported so far. Herein we report a continuous flow difluoromethyl
METHOD FOR PREPARATION OF DIFLUOROMETHYLORNITHINE
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Page/Page column 22-23, (2019/04/16)
The invention discloses a method for preparation of protected difluoromethylornithine by a difluoromethylation of dibenzaldimine ornithine ester using CHF3 and LiHMDS (lithium bis(trimethylsilyl)amide), which can be converted to a salt of unprotected difl
A novel reaction cascade leading to a spontaneous intramolecular dipolar cycloaddition through simultaneous generation of 1,3-dipole and dipolarophile
Kalyanam, Nagabushanam,Rapole, Keshav R,Rajendran, Ramanujam,Majeed, Muhammed
, p. 5155 - 5158 (2013/09/02)
Ornithine methyl ester reacts with aromatic aldehydes to generate bis-Schiff bases, which depending on the structure of the aromatic aldehyde, further undergo an intramolecular cycloaddition through the transient formation of a reactive 1,3-dipole.
