69957-80-8Relevant articles and documents
Nickel(II) Catalyzed Hydroboration: A Route to Selective Reduction of Aldehydes and N-Allylimines
Hossain, Istiak,Schmidt, Joseph A. R.
, p. 1877 - 1884 (2020/05/25)
A cationic [(iminophosphine)nickel(allyl)]+ complex was found to be sufficiently electrophilic to activate aldehydes and N-allylimines to undergo hydroboration with pinacolborane (HBpin) under mild reaction conditions. The catalyst displayed excellent selectivity toward aldehydes in the presence of ketones. A wide variety of functional groups were tolerated, including halogens, NO2, CN, OMe, and alkenes for both aldehydes and imines. Electron-rich substrates were found to be significantly more reactive than their electron poor counterparts, a feature that was correlated to their enhanced ability to coordinate to the Lewis acidic nickel center.
SONIC HEDGEHOG MODULATORS
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Paragraph 0966, (2014/04/17)
Sonic Hedgehog modulators and methods of use thereof are provided for.
A one-pot, three-component synthesis of thiazolidine-2-thiones
Ziyaei-Halimehjani, Azim,Marjani, Katayoun,Ashouri, Akram
body text, p. 3490 - 3492 (2012/08/27)
An efficient method for the synthesis of thiazolidine-2-thiones is described via regiospecific iodocyclization of an allyl amine, carbon disulfide, and iodine. Dehydrohalogenation of the iodo-derivatives gives thiazole-2(3H)-thiones. In addition, nucleoph