70-09-7

Basic information

• Product Name: 1,4-Benzenedicarboxamide, 2-chloro-N,N-bis(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)-
• CAS NO: 70-09-7
• Molecular Formula: C₂₆H₂₃ClN₆O₂
• Molecular Weight: 486.961
• Mol File: 70-09-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,4-Benzenedicarboxamide, 2-chloro-N,N-bis(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Benzenedicarboxamide, 2-chloro-N,N-bis(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)-(70-09-7)
• EPA Substance Registry System: 1,4-Benzenedicarboxamide, 2-chloro-N,N-bis(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)-(70-09-7)

Safety Data

• Hazardous Substances Data: 70-09-7(Hazardous Substances Data)

Usage

Chemical class

1,4-Benzenedicarboxamides

Use

Textile industry as a dye for synthetic fibers

Appearance

Reddish-brown solid at room temperature

Solubility

Insoluble in water

Color properties

Provides vibrant and long-lasting color to textiles

Popularity

Widely used for dyeing polyester and other synthetic fabrics

Health and environmental impact

Limited information available, requires careful handling and disposal

Chemical structure

Aromatic structure with a 1,4-benzenedicarboxamide backbone and chloro, N,N-bis(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl) substituents

Application

Primarily used in the textile industry for synthetic fibers, such as polyester, due to its colorfastness and ability to provide a long-lasting color.

Upstream product

• 61033-71-4 4-(4,5-dihydro-1H-imidazol-2-yl)-phenylamine 
• 13815-87-7 2-chloro-1,4-benzenedicarbonyl dichloride 
• 1967-31-3 2-chloroterephthalic acid 

Relevant articles and documents

Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli

In Gram-negative bacteria, efflux pumps are able to prevent effective cellular concentrations from being achieved for a number of antibiotics. Small molecule adjuvants that act as efflux pump inhibitors (EPIs) have the potential to reinvigorate existing antibiotics that are currently ineffective due to efflux mechanisms. Through a combination of rigorous experimental screening and in silico virtual screening, we recently identified novel classes of EPIs that interact with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in Escherichia coli. Herein, we present initial optimization efforts and structure-activity relationships around one of those previously described hits, NSC 60339 (1). From these efforts we identified two compounds, SLUPP-225 (17h) and SLUPP-417 (17o), which demonstrate favorable properties as potential EPIs in E. coli cells including the ability to penetrate the outer membrane, improved inhibition of efflux relative to 1, and potentiation of the activity of novobiocin and erythromycin.