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(2-fluorophenyl)phosphonic acid is an organic compound with the chemical formula C6H6FO2P. It is a derivative of phenylphosphonic acid, where one of the hydrogen atoms on the phenyl ring is replaced by a fluorine atom. This modification introduces unique electronic and steric properties to the molecule, which can significantly alter its reactivity and binding characteristics compared to the parent compound. (2-fluorophenyl)phosphonic acid is a white crystalline solid that is soluble in organic solvents. It is used in the synthesis of various pharmaceuticals and agrochemicals due to its potential to modulate the activity of enzymes and receptors. The presence of fluorine can enhance the lipophilicity and metabolic stability of the resulting compounds, making it a valuable building block in medicinal chemistry.

700-24-3

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700-24-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 700-24-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,0 and 0 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 700-24:
(5*7)+(4*0)+(3*0)+(2*2)+(1*4)=43
43 % 10 = 3
So 700-24-3 is a valid CAS Registry Number.

700-24-3Downstream Products

700-24-3Relevant academic research and scientific papers

Synthesis and proton dissociation properties of arylphosphonates: A microwave-assisted catalytic arbuzov reaction with aryl bromides

Keglevich, Gyoergy,Gruen, Alajos,Boelcskei, Adrienn,Drahos, Laszlo,Kraszni, Marta,Balogh, Gyoergy T.

, p. 574 - 582 (2013/01/15)

A series of substituted diethyl arylphosphonates was synthesized by the microwave-assisted Arbuzov reaction of triethyl phosphite and aryl bromides in the presence of NiCl2 as the catalyst under solvent-free conditions in good yields. The resulting phosphonates were hydrolyzed to the corresponding arylphosphonic acids whose acidity was evaluated by physicochemical methods.

Synthesis of symmetrical triarylphosphines from aryl fluorides and red phosphorus: Scope and limitations

Schull, Terence L.,Brandow, Susan L.,Dressick, Walter J.

, p. 5373 - 5376 (2007/10/03)

The reaction of aryl fluorides with phosphide anion, generated in situ from the reduction of red phosphorus by lithium metal in liquid ammonia, gave symmetrical triarylphosphines in fair to good yields. Phosphonodiamide, sulfonamide, 2-oxazolyl, and nitrile groups were stable to the reaction conditions, while nitro and bromo substituents were not. para-Substituted aryl fluorides gave higher yields than meta-substituted aryl fluorides, and ortho-substituted aryl fluorides failed to react.

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