7000-88-6Relevant articles and documents
A simple and effective procedure for the N-permethylation of amino-substituted naphthalenes
Sorokin, Vladimir I.,Ozeryanskii, Valery A.,Pozharskii, Alexander F.
, p. 496 - 498 (2007/10/03)
A wide range of amino-substituted naphthalenes can be N-permethylated by the system Me2SO4/Na2CO3/ H2O(alcohols) with good to excellent yields. Steric hindrance does not prevent the reaction. Some amines with electron-withdrawing groups, especially at nonconjugated positions, are also alkylated. The procedure allows the combination of a reduction (catalytic or by tin dichloride in acidic media) and a methylation in a one-pot process. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).