70001-45-5 Usage
Description
4-Fluoro-N-isopropylbenzamide, also known as 4FIB, is a chemical compound with the molecular formula C10H12FNO. It is a white crystalline powder that serves as a building block in the synthesis of pharmaceuticals and agrochemicals. As a benzamide derivative, 4FIB contains a fluorine atom and an isopropyl group, making it a valuable research chemical in the development of new drugs. 4-Fluoro-N-isopropylbenzamide has been studied for its potential therapeutic applications in pain management and is also utilized as a ligand in biochemical research. However, its safety and potential environmental impact should be carefully considered before its use in industrial and research applications.
Uses
Used in Pharmaceutical Synthesis:
4-Fluoro-N-isopropylbenzamide is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs due to its unique chemical structure and properties.
Used in Agrochemical Synthesis:
In the agrochemical industry, 4-Fluoro-N-isopropylbenzamide is used as a building block for the synthesis of agrochemicals, potentially enhancing crop protection and yield.
Used in Pain Management Research:
4-Fluoro-N-isopropylbenzamide is used as a research chemical in the study of pain management, exploring its potential therapeutic applications for treating various types of pain.
Used as a Ligand in Biochemical Research:
In biochemical research, 4-Fluoro-N-isopropylbenzamide is used as a ligand, aiding in the understanding of molecular interactions and mechanisms within biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 70001-45-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,0,0 and 1 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 70001-45:
(7*7)+(6*0)+(5*0)+(4*0)+(3*1)+(2*4)+(1*5)=65
65 % 10 = 5
So 70001-45-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H12FNO/c1-7(2)12-10(13)8-3-5-9(11)6-4-8/h3-7H,1-2H3,(H,12,13)
70001-45-5Relevant articles and documents
Synthesis method of lapatinib intermediate
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Paragraph 0028; 0029, (2021/05/01)
The invention discloses a synthesis method of a lapatinib intermediate, and belongs to the technical field of organic synthesis. The method comprises the following steps: performing carboxyl protection on p-fluorobenzoic acid serving as a raw material and adding acetyl at an ortho-position to obtain a compound IV, performing chiral reduction on the compound IV to obtain a compound V with S configuration, performing Mitsunobu reaction on the compound V and 3-hydroxy-2-nitropyridine to obtain a compound VI with R configuration, performing reaction on the compound VI and hydrochloric acid methanol to obtain a compound VII, and performing recrystallization to obtain the compound VII. and finally, performing nitro-reduction to obtain products. The method has the advantages that the initial raw materials are cheap and easy to obtain (the price of p-fluorobenzoic acid is far lower than that of the raw materials in the prior art), the stereoselectivity is good, chiral resolution is not needed, the total yield is high (the existing yield is about 20%, and the patent is larger than 40%), and a feasible scheme is provided for lapatinib process research.
Chemoselective synthesis of naphthylamides and isoquinolinones via rhodium-catalyzed oxidative dehydrogenative annulation of benzamides with alkynes
Shi, Zhuangzhi,Tang, Conghui,Jiao, Ning
supporting information, p. 2695 - 2700 (2013/01/15)
A rhodiumACHTUNGTRENUNG(III)-catalyzed direct dehydrogenative annulation of benzamides with alkynes through chelating-assisted C-H activation has been developed. Naphthylamide and isoquinolinone derivatives can be chemoselectively obtained by this protoco