70027-03-1

Basic information

• Product Name: Benzoic acid, 4-(5-phenyl-2H-tetrazol-2-yl)-
• CAS NO: 70027-03-1
• Molecular Formula: C14H10N4O2
• Molecular Weight: 266.259
• Mol File: 70027-03-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(5-phenyl-2H-tetrazol-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(5-phenyl-2H-tetrazol-2-yl)-(70027-03-1)
• EPA Substance Registry System: Benzoic acid, 4-(5-phenyl-2H-tetrazol-2-yl)-(70027-03-1)

Safety Data

• Hazardous Substances Data: 70027-03-1(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 1666-16-6 N-benzylidene-N'-benzenesulfonylhydrazone 
• 150-13-0 4-amino-benzoic acid 

Relevant articles and documents

Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker

Target-identification phenotypic screening has been a powerful approach in drug discovery; however, it is hindered by difficulties in identifying the underlying cellular targets. To address this challenge, we have combined phenotypic screening of a fully functionalized small-molecule library with competitive affinity-based proteome profiling to map and functionally characterize the targets of screening hits. Using this approach, we identified ANXA2, PDIA3/4, FLAD1, and NOS2 as primary cellular targets of two bioactive molecules that inhibit cancer cell proliferation. We further demonstrated that a panel of probes can label and/or image annexin A2 (a cancer biomarker) from different cancer cell lines, thus providing opportunities for potential cancer diagnosis and therapy.